Sharanya Arcot Desai

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Deep Brain Stimulation (DBS) has provided remarkable relief to patients with brain disorders. Traditionally, DBS is performed through a single macroelectrode implanted at a specific deep brain structure (like the subthalamic nucleus for Parkinson's disease). Despite its great success, little is known about its mechanisms of action. We propose that using(More)
Direct electrical stimulation of the brain is an increasingly popular means of treating refractory epilepsy. Although there has been moderate success in human trials, the rate of seizure freedom does not yet compare favorably to resective surgery. It therefore remains critical to advance experimental investigations aimed toward understanding brain(More)
OBJECTIVE Subacute and long-term electrocorticographic (ECoG) changes in ambulatory patients with depth and cortical strip electrodes were evaluated in order to determine the length of the implant effect. METHODS ECoG records were assessed in patients with medically intractable epilepsy who had depth and/or strip leads implanted in order to be treated(More)
Implantable microelectrode arrays (MEAs) have been a boon for neural stimulation and recording experiments. Commercially available MEAs have high impedances, due to their low surface area and small tip diameters, which are suitable for recording single unit activity. Lowering the electrode impedance, but preserving the small diameter, would provide a number(More)
BACKGROUND Electrical brain stimulation has shown promise for reducing seizures in drug-resistant epilepsy, but the electrical stimulation parameter space remains largely unexplored. New stimulation parameters, electrode types, and stimulation targets may be more effective in controlling seizures compared to currently available options. HYPOTHESIS We(More)
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