Sharada Mayee Swain

Learn More
Two large multicenter placebo controlled trials (088001 and 088006) in metastatic breast cancer found a significant cardioprotective effect of dexrazoxane when administered with doxorubicin. A delayed dose analysis found a protective effect even after a cumulative dose of doxorubicin of 300 mg/m2. Exploratory analysis combing the arms on the two studies(More)
This multicenter single-arm phase II study evaluated the addition of pazopanib to concurrent weekly paclitaxel following doxorubicin and cyclophosphamide as neoadjuvant therapy in human epidermal growth factor receptor (HER2)-negative locally advanced breast cancer (LABC). Patients with HER2-negative stage III breast cancer were treated with doxorubicin 60(More)
Purpose. Dasatinib is an oral tyrosine kinase inhibitor (TKI) of BCR-ABL and SRC family and ixabepilone is an epothilone B analog. Synergistic activity has been reported when combining dasatinib with chemotherapy. This study was conducted to determine the dose-limiting toxicities (DLTs) and the maximum tolerated doses (MTDs) for this combination. Patients(More)
Breast cancer is the most common malignancy in women. Screening mammography can detect cancer in its early stages, when it is potentially curable. Adjuvant chemotherapy is of major benefit in node-positive patients. It is also beneficial in certain node-negative patients with a high risk of breast cancer recurrence; these patients should be identified and(More)
Abstract: The regulation and fine tuning of airway caliber is basically determined by the bronchial tone through airway smooth muscle contraction and relaxation, wherein the autonomic nervous system has an important role. Here, we have compared Salbutamol (β2 adrenergic agonist) and Ipratropium bromide (M2 muscarinic antagonist). Previous studies focused(More)
  • 1