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BACKGROUND Altered Cl- homeostasis and GABAergic function are associated with nociceptive input hypersensitivity. This study investigated the role of two major intracellular Cl- regulatory proteins, Na+-K+-Cl- cotransporter 1 (NKCC1) and K+-Cl- cotransporter 2 (KCC2), in neuropathic pain following spinal cord injury (SCI). RESULTS Sprague-Dawley rats(More)
Venous outlet obstruction has recently been reported to be a potentially treatable cause of benign intracranial hypertension (BIH). In the English-language literature only 18 cases, all from the UK and Australia, involving the use of transverse sinus stenosis stent treatment for BIH have been reported; the youngest patient to receive treatment was a(More)
OBJECT Several retrospective studies have demonstrated higher accuracy rates and increased safety for navigated pedicle screw placement than for free-hand techniques; however, the accuracy differences between navigation systems has not been extensively studied. In some instances, 3D fluoroscopic navigation methods have been reported to not be more accurate(More)
BACKGROUND Transforaminal lumbar interbody fusion with bilateral segmental pedicle screw (PS) fixation is a widely used and well-recognized technique that provides fixation and load-bearing capacity, while restoring morphometric spine parameters and relieving symptoms in patients with degenerative disc disease. A supplemental interspinous process fixation(More)
STUDY DESIGN A retrospective chart review study was performed. OBJECTIVE The primary objective of this study was to analyze our preliminary results to examine whether it is safe and effective to perform instrumented lumbar interbody fusions on an outpatient basis by comparing 2 groups of patients who were discharged the same day versus those who stayed(More)
OBJECT The goal of the present study goal was to systematically confirm the previously recognized nomenclature for tethering tracts that are part of the spectrum of occult spinal dysraphic lesions. METHODS The tethering tract in 20 patients with spina bifida occulta underwent histological examination with H & E staining and epithelial membrane antigen(More)
BACKGROUND The optimal treatment for hepatic metastases from neuroendocrine tumors remains controversial because of the often indolent nature of these tumors. We sought to determine the effect of 3 major treatment modalities including medical therapy, hepatic artery embolization, and surgical resection, ablation, or both in patients with liver-only(More)
STUDY DESIGN Retrospective case series. OBJECTIVE To compare different interbody reconstruction implants after corpectomy in metastatic spine tumors. SUMMARY OF BACKGROUND DATA Vertebral body reconstruction after corpectomy is common for patients with metastatic spine tumors. Although various implants are reported individually in the literature, no(More)
STUDY DESIGN A preintervention and postintervention design was used to examine a total of 200 patients. OBJECTIVE After successful implementation at our institution of a perioperative oral multimodal analgesia protocol in major joint arthroplasty, a modified regimen was provided to patients undergoing spine procedures. SUMMARY OF BACKGROUND DATA A(More)
OBJECT Children with spina bifida occulta require early surgery to prevent neurological deficits. The treatment of patients with a congenitally tethered cord who present in adulthood remains controversial. METHODS The authors studied the medical records of 61 adult patients who underwent surgical untethering for spina bifida occulta at three institutions(More)