Shaozhen Zhang

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Background Human reproduction depends on the fusion of a mature oocyte with a sperm cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte maturation are unknown. Methods We sequenced the exomes of five members of a four-generation family, three of whom had infertility due to oocyte meiosis I arrest. We performed Sanger(More)
OBJECTIVE To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction. DESIGN Retrospective cohort study. SETTING Academic tertiary-care medical center. PATIENT(S) At total of 150 infertile patients undergoing in vitro fertilization (IVF)(More)
Steroid synthesis and metabolic pathways play important roles in the pathophysiology of PCOS, but until now there have been no studies on the methylation profiles of specific genes in steroid synthesis pathways that are known to be associated with PCOS. Here we used MassARRAY quantitative methylation analysis to determine the methylation levels of each CpG(More)
Epigenetic mechanisms may contribute to polycystic ovary syndrome (PCOS). To date, however, no studies have associated CpG methylation levels of any candidate gene with PCOS susceptibility. Follistatin (FST), an activin-binding protein, is expressed in numerous tissues and is shown to have linkage with PCOS. However, results from case-control association(More)
BACKGROUND The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor responders. This study aimed to explore the follicular dynamics in P-primed minimal stimulation in poor responders. METHODS A total of 204(More)
Advances in development and deployment of mobile business applications (MBAs) based on the hybrid Web approach (hybrid MBAs) create new possibilities for enterprises to mobilize their business processes (BPs). Despite the fact that variability has a natural appearance in complex environments among different enterprises, current development tools for hybrid(More)
OBJECTIVE To study if hysteroscopy and short-term copper intrauterine device placement (Cu-IUD) improves the pregnancy rates of women with repeated implantation failure (RIF) undergoing frozen-thawed embryo transfer (FET). DESIGN Retrospective study. SETTING Medical university hospital. PATIENT(S) Infertile women with at least two implantation(More)
OBJECTIVES To apply the three-dimensional (3D) hysterosalpingo-contrast sonography (HyCoSy) with perfluoropropane-albumin microspheres as contrast agents and normal saline injections into the pelvic cavity for assessment of the tubal patency and adhesions of fimbrial parts. METHODS Fifty-five infertile female patients were recruited to undergo 3D HyCoSy(More)
  • Jie Zhang, Yun Wang, +5 authors Yanping Kuang
  • Reproductive biomedicine online
  • 2017
Previous studies show that a dual trigger ovulation regimen significantly improves number and maturity of retrieved oocytes for normal ovarian responders or patients with history of low oocyte yield. The current retrospective cohort study investigated whether dual trigger of final oocyte maturation may benefit IVF outcomes for poor ovarian responders(More)
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