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One pepsinogen C gene was cloned from the gastric mucosa of orange-spotted grouper (Epinephelus coioides) for the first time. This gene consisted of nine exons interrupted by eight introns. The nucleotide sequence with the coding region and 3'-flanking region was also determined. The deduced polypeptide sequence was composed of a prosegment of 55 residues(More)
Chitinase, belonging to either family 18 or family 19 of the glycosylhydrolases, hydrolyze chitin into oligosaccharides. In the present study, the cDNA fragment encoding orange-spotted grouper (Epinephelus coioides) chitinase1 was subcloned into pPIC3.5K vector and expressed in Pichia pastoris GS115. The results showed that a band with the size of about 53(More)
Our recent genome-wide association study (GWAS) had discovered a new locus at 8p23 (rs2738048) associated with IgA nephropathy (IgAN) in Chinese Han patients, implicating the DEFA gene family within this locus as susceptibility genes. However, it is still unknown whether there are additional variations within these genes associated with the disease(More)
BACKGROUND The effect of high peritoneal dialysate glucose concentration (PDGC) on all-cause and cardiovascular disease (CVD) mortality in peritoneal dialysis (PD) patients is unclear. OBJECTIVE Our study aimed to investigate the effect of high PDGC on all-cause and CVD mortality in continuous ambulatory PD (CAPD) patients. METHODS The study enrolled(More)
OBJECTIVE It was reported that subgroup J avian leukosis virus strain NX0101 activates PI3K/Akt pathway during early infection in DF-1 cells. Whether there is YXXM motif in the amino acid sequence of NX0101 and the function of YXXM motif were studied. METHODS The presence of internal transmembrane domains in the envelope protein of NX0101 was analyzed by(More)
Although a major source of genetic variation, copy number variations (CNVs) and their involvement in disease development have not been well studied. Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We performed association analysis of the DEFA1A3 CNV locus in two independent IgAN cohorts of southern Chinese Han(More)
PURPOSE Smad3 is a critical signaling protein in renal fibrosis. Proteolysis targeting chimeric molecules (PROTACs) are small molecules designed to degrade target proteins via ubiquitination. They have three components: (1) a recognition motif for E3 ligase; (2) a linker; and (3) a ligand for the target protein. We aimed to design a new PROTAC to prevent(More)
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