Shaoyu Zhou

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Aluminum (Al(3+)) is the most prevalent metal in the earth's crust and is a known human neurotoxicant. Al(3+) has been shown to accumulate in the substantia nigra of patients with Parkinson's disease (PD), and epidemiological studies suggest correlations between Al(3+) exposure and the propensity to develop both PD and the amyloid plaque-associated disorder(More)
The mechanism linking p53 inactivation to human cell malignancy remains unclear. Studies have indicated that mitochondrial dysfunction is involved in carcinogenesis. In this study we investigated the role of p53 in mitochondrial DNA (mtDNA) mutation and maintenance of proper mitochondrial function. We measured mtDNA mutation and found no difference in(More)
Interference with mitochondrial calcium regulation is proposed to be a primary causative event in the mechanism of doxorubicin-induced car-diotoxicity. We previously reported disruption of mitochondrial calcium homeostasis after chronic doxorubicin administration (Solen et al. Toxicol. The present study was designed to characterize the dose-dependent and(More)
The way in which data is distributed across the processing elements of a parallel shared-nothing architecture can have a signiicant eeect on the performance of a parallel DBMS. Data placement strategies provide a mechanical approach to determining a data distribution which will provide good performance. However, there is considerable variation in the(More)
Methods for estimating the performance of DBMSs can aid the design of database systems by identifying potential performance bottlenecks or by predicting the relative performance of diierent designs. Performance estimation is critical in parallel database systems with distributed memory where an eeective overall performance depends on a good choice among a(More)
BACKGROUND Somatic mutations of mitochondrial DNA (mtDNA) are common in many human cancers. We have described an oligonucleotide microarray ("MitoChip") for rapid sequencing of the entire mitochondrial genome (Zhou et al, J Mol Diagn 2006), facilitating the analysis of mtDNA mutations in preneoplastic lesions. We examined 14 precancerous lesions, including(More)
Cache modelling is an important issue in developing an analytical performance evaluator to estimate performance for applications running on parallel DBMSs. This paper describes a cache model developed for parallel cache management in Oracle7 Parallel Server. Some preliminary results have also been obtained by using the cache model to predict cache hit(More)
Parallel database systems are generally recognised as one of the most important application areas for commercial parallel systems. However, the task of managing the performance of a parallel database system is exceedingly complex. The initial choice of hardware conngura-tion to support a particular DBMS application and the subsequent task of tuning the DBMS(More)