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Gross changes in nuclear morphology are a standard criteria used in the diagnosis of many cancers. Cancerous cells are characterized by enlarged nuclei and prominent nucleoli. However, the specific nuclear components involved, the underlying mechanisms, and the implications for cancer progression, are far from clear. The nuclear lamina, a scaffold-like(More)
Most chemotherapeutical drugs kill cancer cells chiefly by inducing DNA damage, which unfortunately also causes undesirable injuries to normal tissues, mainly due to p53 activation. We report a novel strategy of normal tissue protection that involves p53/NF-κB coordinated metabolic regulation. Pretreatment of untransformed cells with low doses of arsenic(More)
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