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- Ganesh Mani Shankar, Shaomin Li, +11 authors Dennis J Selkoe
- Nature Medicine
- 2008
Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing… (More)
In Alzheimer's disease (AD), the impairment of declarative memory coincides with the accumulation of extracellular amyloid-beta protein (Abeta) and intraneuronal tau aggregates. Dementia severity… (More)
- Shaomin Li, William K. Cullen, Roger Anwyl, Michael J. Rowan
- Nature Neuroscience
- 2003
In addition to its role in memory formation, the hippocampus may act as a novelty detector. Here we investigated whether attention to novel events can promote the associative synaptic plasticity… (More)
- Soyon Hong, Victoria F. Beja-Glasser, +10 authors Beth Stevens
- Science
- 2016
Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we… (More)
- Shaomin Li, Ming Jin, Thomas Koeglsperger, Nina E. Shepardson, Ganesh Mani Shankar, Dennis J Selkoe
- The Journal of neuroscience : the official…
- 2011
In Alzheimer's disease (AD), dementia severity correlates strongly with decreased synapse density in hippocampus and cortex. Numerous studies report that hippocampal long-term potentiation (LTP) can… (More)
- Shaomin Li, Xuejun Tian, Dean M. Hartley, Larry A. Feig
- The Journal of neuroscience : the official…
- 2006
NMDA-type glutamate receptors (NMDARs) contribute to many forms of long-term potentiation (LTP) and long-term depression (LTD). NMDARs are heteromers containing calcium-permeating neuronal receptor 1… (More)
- Tao Yu, Zhongyou Li, +18 authors Yuejin E. Yu
- Human molecular genetics
- 2010
Down syndrome (DS) is caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genetic cause for developmental cognitive disability. The regions on Hsa21 are… (More)
- Shaomin Li
- 2005
Abstract It is widely believed that countries with a poor governance environ-ment (e.g., weak laws and rampant corruption) do not attract foreign directinvestment (FDI); however, our study suggests… (More)
Manuscript Type: Empirical
Research Question/Issue: Effective corporate governance requires accurate and reliable financial information. Historically, each nation has developed and pursued its own… (More)
- Shaomin Li, Ming Jin, +4 authors Dennis J Selkoe
- Neuron
- 2013
A central question about human brain aging is whether cognitive enrichment slows the development of Alzheimer changes. Here, we show that prolonged exposure to an enriched environment (EE)… (More)