• Publications
  • Influence
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
Notch receptor signaling regulates cell growth and differentiation, and core components of Notch signaling pathways are conserved from Drosophila to humans. Fringe glycosyltransferases are crucialExpand
  • 337
  • 22
  • PDF
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.
Dicer is an enzyme that generates microRNA (miRNA), which are small, noncoding RNA that function as important regulators of gene and protein expression. For exploration of the functional roles ofExpand
  • 299
  • 10
  • PDF
Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis.
Focal segmental glomerular sclerosis (FSGS) is a primary kidney disease that is commonly associated with proteinuria and progressive loss of glomerular function, leading to development of chronicExpand
  • 160
  • 7
  • PDF
Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling*
Mammalian Notch receptors contain 29–36 epidermal growth factor (EGF)-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an essential component of the canonical NotchExpand
  • 151
  • 7
  • PDF
The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.
Mammary alveoli are composed of luminal (secretory) and basal (myoepithelial) cells, which are descendants of a common stem cell. This study addressed the role of RBP-J-dependent Notch signaling inExpand
  • 133
  • 6
Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility
The molecular signaling mechanisms between glomerular cell types during initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We compared the early transcriptome profileExpand
  • 73
  • 6
Canonical Notch Signaling Is Dispensable for Early Cell Fate Specifications in Mammals
ABSTRACT The canonical Notch signaling pathway mediated by Delta- and Jagged-like Notch ligands determines a variety of cell fates in metazoa. In Caenorhabditis elegans and sea urchins, canonicalExpand
  • 55
  • 6
Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies
The progression of podocytopathies is quite variable among patients and the underlying reason for this remains unclear. Here, we report that autophagic activity in podocytes plays a critical role inExpand
  • 43
  • 5
  • PDF
Inactivation of the Mgat1 Gene in Oocytes Impairs Oogenesis, but Embryos Lacking Complex and Hybrid N-Glycans Develop and Implant
ABSTRACT Complex and hybrid N-glycans contain sugar residues that have been implicated in fertilization, compaction of the embryo, and implantation. Inactivation of the Mgat1 gene responsible forExpand
  • 84
  • 4
  • PDF
The Threonine That Carries Fucose, but Not Fucose, Is Required for Cripto to Facilitate Nodal Signaling*
Cripto is a membrane-bound co-receptor for Nodal, a member of the transforming growth factor-β superfamily. Mouse embryos lacking either Cripto or Nodal have the same lethal phenotype at embryonicExpand
  • 57
  • 3
  • PDF