Shaojiang Cai

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The Mozambique tilapia Oreochromis mossambicus has the ability to adapt to a broad range of environmental salinities and has long been used for investigating iono-osmoregulation. However, to date most studies have focused mainly on several key molecules or parameters hence yielding a limited perspective of the versatile iono-osmoregulation in the euryhaline(More)
Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. Using whole-genome(More)
Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in open chromatin and shaped by chromatin structure. We identified seven rearrangement hot spots and 136 gene(More)
Currently, submission of new SNP entries into SNP repositories such as dbSNP by NCBI is done by manual curation. This gives rise to errors and ambiguities in SNP data entries. Due to the exponential increase in SNP discovery, there is a necessity to create algorithms to accurately and rapidly map SNPs as they are discovered in real time and depositing these(More)
SNP (Single Nucleotide Polymorphism), the most common genetic variations between human beings, is believed to be a promising way towards personalized medicine. As more and more research on SNPs are being conducted, non-standard nomenclatures may generate potential problems. The most serious issue is that researchers cannot perform cross referencing among(More)
Users’ attention is generally allocated in a rather inequitable manner on social media platforms (SMP). An important question for both researchers and practitioners is: how and why do the popular contents get popular? Previous studies have investigated this question from diverse perspectives. In this study, we propose that the time when the content is(More)
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