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Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport.
The Niemann Pick C1 protein localizes to late endosomes and plays a key role in the intracellular transport of cholesterol in mammalian cells. Cholesterol and other lipids accumulate in a lysosomalExpand
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Studying Membrane Biogenesis with a Luciferase-Based Reporter Gene Assay
To study the coordination of different lipid synthesis pathways during membrane biogenesis it is useful to work with an experimental system where membrane biogenesis occurs rapidly and in anExpand
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Effects of GSK 2606414 on cell proliferation and endoplasmic reticulum stress ‐ associated gene expression in retinal pigment epithelial cells
GSK2606414 is a novel, highly selective inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK). GSK2606414 and its analogues have recently been demonstrated to delay tumor growth andExpand
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Intravitreal injection of docosahexaenoic acid attenuated photoreceptor cell injury in a NaIO3-induced age-related macular degeneration rat model
In most studies, the major supplement docosahexaenoic acid (DHA) is administered orally or intraperitoneally. In this study, we proposed to assess the safety and efficacy of the intravitrealExpand
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