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Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis
TLDR
The results suggest that the differences in the Kunitz/BPTI family between soft and hard ticks may be linked to the evolution of long-term blood feeding in hard ticks.
Folate Deficiency and Gene Polymorphisms of MTHFR, MTR and MTRR Elevate the Hyperhomocysteinemia Risk.
TLDR
It is demonstrated that the joint effect of homocysteine metabolism gene polymorphisms and folate deficiency lead to dramatic elevations in the HHcy risk.
Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes.
TLDR
A meta-analysis with 9 microarray datasets of PD and AD studies found that MAFF was upregulated in all tissues and significantly negatively correlated with the 31 NRF2-dependent genes in diseased conditions, suggesting it might play an important role in dysfunction ofNRF2 regulatory network in PD.
Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency
TLDR
The results of this study have shown that interactions among homocysteine metabolism gene polymorphisms lead to dramatic elevations in the folate deficiency risk.
Azvudine, A Novel Nucleoside Reverse Transcriptase Inhibitor Showed Good Drug Combination Features and Better Inhibition on Drug-Resistant Strains than Lamivudine In Vitro
TLDR
The present data demonstrates the potential of azvudine as a complementary drug to current anti-HIV drugs and its drug resistance features and Molecular modeling analysis suggests that steric hindrance is more pronounced in mutant M184I than M184V due to the azido group of azVudine.
In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database
TLDR
The study suggests that the predicted compounds and plants from TCM database offer an attractive starting point and a broader scope to mine for potential anti-cancer agents.
Low expression of aging-related NRXN3 is associated with Alzheimer disease
TLDR
Interestingly, NRXN3, the second most commonly deregulated gene identified in the present study, is known to carry a mutation in AD patients, and plays a critical role in synaptic functions involved in the cognitive decline associated with normal aging and AD.
Different impairment of immune and inflammation functions in short and long-term after ischemic stroke.
TLDR
Large differences of altered immune and inflammation functions based on gene levels between short and long-term after stroke onset are identified, providing valuable insight into the clinical practice and prognosis evaluation of ischemic stroke.
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study
TLDR
Low folate status and homocysteine metabolism gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) may have a synergistic effect increased the incidence of dyslipidemia in Chinese hypertensive population.
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