Shao-fei Yuan

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OBJECTIVE To explore whether monoclonal antibodies against stathmin and the chemotherapuetic agent paclitaxel have synergenic effects in inhibiting growth and inducing apoptosis in human QG-56 cells. METHODS QG-56 cells were treated with monoclonal antibodies against stathmin or paclitaxel alone or in combination, with untreated cells used as controls.(More)
AIMS To investigate the relationship between the expression of β-tubulin III and survivin in advanced breast cancers and chemotherapeutic effects of docetaxel. METHODS Clinical pathological data of 74 patients with advanced breast cancer were retrospectively analyzed after docetaxel chemotherapy. Expression of β-tubulin III and survivin was assessed by(More)
PURPOSE To study the roles of βIII-tubulin and survivin in the development of gastric cancer, and see for any relationship between the expression levels of these two genes and docetaxel chemoresistance in advanced gastric cancer. METHODS Patients with advanced gastric cancer treated with docetaxel-based chemotherapy were enrolled and their tumor samples(More)
OBJECTIVE The current prospective randomized study was designed to evaluate the safety and efficacy of combined intrapleural cisplatin and OK-432 (picibanil) plus hyperthermotherapy in patients with malignant pleural effusion (MPE). METHODS A total of 358 patients with MPE due to end-stage malignancies were enrolled and randomly divided into two groups, A(More)
AIM To investigate the effectiveness and adverse effects of gemcitabine by fixed-dose rate infusion plus oxaliplatin (GEMOX regimen) as second-line therapy for advanced ovarian cancer. METHODS 64 patients with advanced ovarian cancer were divided into an experimental group (44 cases) and a control group (20 cases). The experimental group was treated with(More)
Lung cancer is one of the most harmful malignant tumors to human health and life, and its incidence is increasing every year, and ranking the first in large and medium-sized cities in the incidence of malignant tumors. 2/3 of patients are in advanced stage when diagnosed as lung cancer and lose the opportunity of surgical treatment. Chemotherapy is(More)
OBJECTIVE To obtain monoclonal antibodies (mAb) against LI-cadherin and investigate their effects on the proliferation of human hepatocellular carcinoma cells. METHODS Balb/c mice were immunized with recombinant LI-cadherin, and hybridoma cell lines secreting monoclonal antibodies against LI-cadherin were established with routine cell fusion and(More)
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