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Ethanol-induced apoptosis in selected cell populations is a major component of pathogenesis underlying ethanol-induced teratogenesis. However, there is a fundamental gap in understanding how ethanol leads to apoptosis in embryos. In this study, we investigate the role of seven in absentia homolog-1 (Siah1) protein, an E3 ubiquitin ligase, in ethanol-induced(More)
MicroRNAs are a class of small noncoding RNAs that have been implicated in regulation of a broad range of cellular and physiologic processes, including apoptosis. The objective of this study is to elucidate the roles of miR-125b in modulating ethanol-induced apoptosis in neural crest cells (NCCs) and mouse embryos. We found that treatment with ethanol(More)
BACKGROUND The Siberian salamander (Ranodon sibiricus), distributed in geographically isolated areas of Central Asia, is an ideal alpine species for studies of conservation and phylogeography. However, there are few data regarding the genetic diversity in R. sibiricus populations. METHODOLOGY/PRINCIPAL FINDINGS We used two genetic markers (mtDNA and(More)
Previous studies have demonstrated that maternal ethanol exposure induces a moderate increase in Nrf2 protein expression in mouse embryos. Pretreatment with the Nrf2 inducer, 3H-1, 2-dithiole-3-thione (D3T), significantly increases the Nrf2 protein levels and prevents apoptosis in ethanol-exposed embryos. The present study, using PC12 cells, was designed to(More)
Breast cancer is one of the leading causes of death in women. Early detection and treatment plays an important role in decreasing the mortality rate. Ultrasound is increasingly been used as an adjunct to mammography to detect breast tumors. An accurate and reliable tool to assist physicians in making diagnosis and treatment decisions is essential and(More)
Chip Design of a frequency synthesizer with digital calibration and spur reduction method operating at 5.0-GHz band is proposed and fabricated in TSMC 0.18-um CMOS process. The proposed PLL with digital calibration reduces VCO gain, Kvco to achieve better phase noise and spur performance in systems networks and architectures for high end computing. The(More)
A fractional-N frequency synthesizer with dual Loop and loop bandwidth optimization operating at 5.0-GHz band is proposed and fabricated in TSMC 0.18-um CMOS process. The proposed design can be used for the IEEE 802.15.4a unlicensed ultra-wideband healthcare applications such as body sensor network. The proposed PLL with a cross-coupled pair LC-tank(More)
Reactive oxygen species (ROS) induce or protect cellular oxidative damage. ROS are also known to play an important role in apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, cell migration, and invasion. This special issue presents the recent advances in basic research and association studies of some natural products and chemical(More)
Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver. We sought to determine the role of FGF21 in hepatic steatosis in mice exposed to chronic alcohol treatment and to discern underlying mechanisms. Male FGF21 knockout (FGF21 KO) and control (WT) mice were divided into groups that were fed either the(More)
Seven in absentia homolog 1 (Siah1) is one of the E3 ubiquitin ligases and plays a key role in regulating target protein degradation. This study was designed to test the hypothesis that Siah1 mediates ethanol-induced apoptosis in NCCs through p38 MAPK-mediated activation of the p53 signaling pathway. We found that exposure of NCCs to ethanol resulted in the(More)
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