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Chemometric methods in data processing of mass spectrometry-based metabolomics: A review.
This review focuses on recent and potential advances in chemometric methods in relation to data processing in metabolomics, especially for data generated from mass spectrometric techniques.Expand
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Large-scale prediction of drug-target interactions using protein sequences and drug topological structures.
The identification of interactions between drugs and target proteins plays a key role in the process of genomic drug discovery. It is both consuming and costly to determine drug-target interactionsExpand
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Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.
Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factorExpand
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Chemometrics applied to quality control and metabolomics for traditional Chinese medicines.
Traditional Chinese medicines (TCMs) bring a great challenge in quality control and evaluating the efficacy because of their complexity of chemical composition. Chemometric techniques provide a goodExpand
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Large-scale prediction of human kinase-inhibitor interactions using protein sequences and molecular topological structures.
The kinase family is one of the largest target families in the human genome. The family's key function in signal transduction for all organisms makes it a very attractive target class for theExpand
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Purification and characterization of a glucan from Bacillus Calmette Guerin and the antitumor activity of its sulfated derivative.
A water-soluble glucan, BCG-PASW, with a molecular weight of 2.10×10(4)Da, was separated from polysaccharide nucleic acid fraction of Bacillus Calmette Guerin (BCG-PSN) using DEAE-52 cellulose andExpand
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Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber
Fucosylated chondroitin sulfate (FuCS), a kind of complex glycosaminoglycan from sea cucumber, has potent anticoagulant activity. In order to understand the relationship between structures andExpand
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Genome-Scale Screening of Drug-Target Associations Relevant to Ki Using a Chemogenomics Approach
The identification of interactions between drugs and target proteins plays a key role in genomic drug discovery. In the present study, the quantitative binding affinities of drug-target pairs areExpand
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[Separation and purification of alkaloids from radix of Zanthoxylum nitidum by macroporous adsorption resin].
OBJECTIVE To obtain the optimal conditions for separating the alkaloids from the extract of Radix of Zanthoxylum nitidum by selecting appropriate macroporous adsorption resins. METHOD Eight typesExpand
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Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography.
TLDR
A preparative high-speed counter-current chromatography method for separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN was successfully established by using n-hexane-ethyl acetate-methanol-water (5:8:4:5, v/v) as the two-phase solvent system. Expand
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