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Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells.
TLDR
Overexpressing of miR-148a increased autophagic activity, which inhibited proliferation and promoted apoptosis in HSCs, supporting a novel role for miR -148a as a key regulator of autophagy through the Hh signaling pathway.
Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.
TLDR
It is suggested that CBP/p300-mediated acetylation of histones H3 and H4 may be a rate-limiting step for the hypomethylation and activation of these two promoters in HBx-mediated hepatocellular carcinoma.
The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma.
TLDR
Investigation of the relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma (HCC) and to clarify the mechanism of HCC finds point mutation at codon 301 is one of the mechanisms of abnormal over-expression in HCC.
Hypomethylated P4 Promoter Induces Expression of the Insulin-Like Growth Factor-II Gene in Hepatocellular Carcinoma in a Chinese Population
TLDR
IGF-II P4 hypomethylation may be an early and frequent event and that it may contribute to P4 transcription expression activation during the transformation of a premalignant liver lesion to HCC, suggesting a useful biomarker for poor prognosis of patients with HCC.
Ultrasound-Guided Endoscopic Biliary Drainage: A Useful Drainage Method for Biliary Decompression in Patients with Biliary Obstructions
TLDR
Endoscopic biliary drainage (EBD) under US-guidance and under fluoroscopy guidance is equally effective and safe for patients with lower or upper/middle obstructions of the CBD.
The value of model for end‐stage liver disease and Child–Turcotte–Pugh scores over time in evaluating the prognosis of patients with decompensated cirrhosis: experience in the Chinese mainland
TLDR
The ability of the above scoring systems to predict the outcome of decompensated cirrhosis in the Chinese mainland is investigated.
Construction of non-covalent single-chain Fv dimers for hepatocellular carcinoma and their biological functions.
TLDR
ScFv dimers are generated by shortening a series of linkers to 3-5 amino acid residues in VH-linker-VL orientation, resulting in highly stable and affinity-improved dimeric molecules that will become an attractive targeting moiety in immunotherapeutic and diagnostic applications for HCC.
[Relationship between alterations of p16INK4a and p14ARF genes of CDKN2A locus and gastric carcinogenesis].
OBJECTIVE To investigate the relationship between alterations of p16INK4a and p14ARF genes and gastric carcinogenesis. METHODS Tumors and gastric tissues neighboring carcinoma from 48 patients with
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