Shao-Chi Chang

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Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is(More)
The Publication Approved Drug Products with Therapeutic Equivalence Evaluations (commonly known as the Orange Book) identifies drug products approved by the United States Food and Drug Administration (USFDA) for safety and effectiveness, and provides substantial information on new drug applications (NDAs) with patent data. To explore the patterns among drug(More)
BACKGROUND/AIMS During the resolution phase of inflammation, release of "find-me" signals by apoptotic cells is crucial in the chemoattraction of macrophages toward apoptotic cells for subsequent phagocytosis, in which microparticles derived from apoptotic cells (apo-MPs) are involved. A recent study reports that CX3CL1 is released from apoptotic cells to(More)
BACKGROUND Phagocytic clearance of apoptotic neutrophils by tissue macrophages is a crucial component in the resolution phase of acute inflammation. However, the number of tissue macrophages is low and not likely to cope satisfactorily with the excess number of dying neutrophils. Although recent studies have reported that neutrophils are able to engulf(More)
Article history: Received 18 March 2009 Received in revised form 26 June 2009 Accepted 25 August 2009 Available online 4 November 2009 This study investigates whether prior experience of share repurchases matters in the market reactions to the subsequent repurchase announcements. Specifically, we study the prior record on actual buybacks and(More)
This study presents international evidence by examining the wealth effect of minority equity participation in strategic alliances by Taiwanese firms. Consistent with United States evidence, we find that announcements of strategic alliances by Taiwanese firms are, on average, associated with significantly positive abnormal stock returns. We also find that(More)
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