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In order to determine the user's trust is a growing concern for ensuring privacy and security in a cloud computing environment. In cloud, user's data is stored in one or more remote server(s) which poses more security challenges for the system. One of the most important concerns is to protect user's sensitive information from other users and hackers that… (More)
Digital watermarking for relational databases emerged as a candidate solution to provide copyright protection, tamper detection, traitor tracing, maintaining integrity of relational data. Many watermarking techniques have been proposed in the literature to address these purposes. In this paper, we survey the current state-of-the-art and we classify them… (More)
Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.
5'-Deoxy-5'-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5'-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.
Cloud-computing applications are fast replacing traditional mobile and desktop applications such as e-mail, document editing, or photo storage. Such applications may require ubiquitous network access that is not always available, e.g., in remote areas without infrastructure, but also in areas with infrastructure where the costs of access are too high for… (More)
As information hiding, the digital watermark techniques have been attracting more interests in both research and industrial fields. Relational database is widely used in many information systems, as a tool for storing and managing a data. Major issue to protect the copyright of relational data. In order to make watermarking information more intuitive and… (More)
We have established structure-activity relationships of novel truncated D-4'-thioadenosine derivatives from D-mannose as potent and selective A(3) adenosine receptor (AR) antagonists. At the human A(3) AR, most of N(6)-substituted analogues showed high potency and selectivity and acted as pure antagonists in a cyclic AMP functional assay. Among compounds… (More)
A novel, general, and stereoselective route to functionalized bridged bicyclo[2.2.2]octanes, bicyclo[3.3.0]octanes, bicyclo[4.2.0]octanes, and tricyclo[220.127.116.11(3,7)]decanes has been described. Various functionalized and substituted bicyclo[2.2.2]octanes endowed with a beta,gamma-enone chromophore were synthesized via cycloaddition of in situ generated… (More)
Stereoselective synthesis of novel 2',3'-didehydro-2',3'-dideoxy-4'-selenonucleosides (4'-seleno-d4Ns) 4a- c was accomplished via 4'-selenoribofuranosyl pyrimidines 11a- c, as key intermediates. 4'-Selenoribofuranosyl pyrimidines 11a- c were efficiently synthesized from d-ribose or d-gulonic gamma-lactone using a Pummerer-type condensation as a key step.… (More)
On the basis of potent and selective A(3) adenosine receptor (AR) antagonist, 2-chloro-N(6)-(3-iodobenzyl)-4'-thioadenosine-5'-N,N-dimethyluronamide, structure-activity relationships were studied for a series of 5'-N,N-dialkyluronamide derivatives, synthesized from D-gulonic gamma-lactone. From this study, it was revealed that removal of the hydrogen… (More)