Shantala R Naik

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BACKGROUND The Toll protein in Drosophila regulates dorsal ventral patterning during embryogenesis, and participates in antibacterial and antifungal host defense. Mammalian homologues are termed Toll-like receptors and, to date, nine have been cloned (TLRI-9) in humans. They are characterized by extracellular leucine-rich repeats and a cytoplasmic domain(More)
We performed transesophageal two-dimensional echocardiography (TEE) and compared its results with those of transthoracic echocardiography (TTE) in a series of 120 patients with rheumatic mitral stenosis (MS). The patients were selected from a pool of 2000 patients of rheumatic heart disease assessed earlier by clinical examination and TTE. The selection(More)
AIM The study was designed to evaluate the serum interleukin-8 (IL-8) levels in patients with recurrent aphthous ulcer (RAU) and monitor the immunomodulation and altered IL-8 levels by levamisole before therapy and after levamisole therapy. MATERIALS AND METHODS This study was carried as a randomized case-control study involving a study group of 30(More)
Cemento-ossifying fibroma (COF) is considered a benign osseous tumor. Herewith, we present a case of multiple central ossifying fibroma in a 35-yeaold woman. Intraorally, there was swelling in the left upper posterior teeth region and another diffused swelling in the fourth quadrant. Radiographs revealed the presence of well-defined mixed(More)
Ossifying fibromas are well-demarcated benign fibro-osseous tumors of craniofacial skeleton most often in the jaws. It has two types, conventional and juvenile ossifying fibroma (JOF). JOF is considered a separate entity from ossifying fibroma due to its locally aggressive behavior and tendency to occur at a young age. Two subtypes of JOF, i.e., juvenile(More)
Candida may play a role in the etiopathogenesis of premalignant and malignant lesions. The aim of the study was to isolate and identify Candida species from the oral cavity with HiCrome candida differential agar plate. It is a new chromogenic culture media that allows the isolation and identification of species on the basis of coloured colony formation.(More)
We are becoming increasingly aware of inherited genetic abnormalities as causes of disease. However, alterations in gene expression can also contribute to other disease processes. Recently it has been suggested that our environment may alter such genes and thus be a direct influence on disease. Diet is a potent mechanism for altering the environment of(More)
Aplasia of the mandibular condyle is extremely rare when not seen in association with or as a part of any syndrome. The incidence is estimated to be 1 in 5,600 births. Growth disturbances in the development of the mandibular condyle may occur in utero late in the first trimester and may result in disorders, such as aplasia or hypoplasia of the mandibular(More)
OBJECTIVES We hypothesised that nonadherence to thiopurines is more common in adolescents than in adults with inflammatory bowel disease. METHODS We sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels. RESULTS Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence(More)
OBJECTIVES Children with Crohn's disease grow poorly, and inflammation depresses the response of insulin-like growth factor-1 (IGF-1) to growth hormone. Correcting the inflammation normalises growth velocity; however, removing inflammation cannot be achieved in all children. Our lack of understanding of IGF-1 kinetics has hampered its use, particularly as(More)
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