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Can the coronavirus disease be transmitted from food? A review of evidence, risks, policies and knowledge gaps
TLDR
It is hypothesize that contaminated cold-storage foods may present a systematic risk for SARS-CoV-2 transmission between countries and regions, and review the evidence, risk factors, current policy and knowledge gaps. Expand
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
TLDR
Chlorcyclizine HCl (CCZ), an over-the-counter drug for allergy symptoms, is identified and characterized as an anti-HCV drug in vitro and in vivo, and represents a promising candidate for drug repurposing and further development as an effective and accessible agent for treatment of HCV infection. Expand
Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
  • J. Li, Z. Tan, +7 authors Ming Yang
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 15 April 2009
TLDR
15 compounds could block HIV-1 replication by inhibiting the PPIase activity of CypA to interfere with capsid disassembly and disrupting CA assembly with a dose-dependent manner. Expand
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
TLDR
Structural-activity relationship (SAR) efforts that resulted in the optimization of novel chlorcyclizine derivatives as anti-HCV agents can serve as lead preclinical candidates for the treatment of hepatitis C virus infection and as probes to study hepatitis Cirus pathogenesis and host-virus interaction. Expand
Electrostatic fine particles emitted from laser printers as potential vectors for airborne transmission of COVID-19
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 14 million people globally. Recently, airborne transmission has been postulatedExpand
High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.
TLDR
The optimization of the benzofuran scaffold led to the identification of several exemplars with potent inhibition of HCV, low cytotoxicity, and excellent selectivity, and the design and synthesis of a 45-compound library to comprehensively explore the anti-HCV activity. Expand
Urban flooding events pose risks of virus spread during the novel coronavirus (COVID-19) pandemic
TLDR
Given that communities serviced by combined sewer systems are particularly prone to such risks, local municipalities could prioritize wastewater infrastructure upgrades and consider combined sewer separations to minimize the risks of pathogen transmission via sewage overflows during epidemics. Expand
Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds
TLDR
A quantitative high-throughput screening (qHTS) assay platform with a cell-based HCV infection system is developed and effective in identifying novel HCV inhibitors and that it can be readily applied to large-scale screening of small-molecule libraries. Expand
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
TLDR
A new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride, showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leish maniasis model. Expand
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.
TLDR
Stable solids possessed low nanomolar IC(50) values against Trypanosoma brucei rhodesiense STIB900 in vitro and provided cures in an early treatment acute mouse model of African trypanosomiasis when given ip at 50mg/kg/day for four consecutive days. Expand
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