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Inflammatory mediators play a crucial role in the pathophysiology of several neurodegenerative diseases including acquired immune deficiency syndrome dementia complex. In the present study we identified a link between CXCL10 overexpression in the brain and human immunodeficiency virus dementia and demonstrated the presence of the chemokine CXCL10 and its(More)
Chemokines play a key role in the regulation of central nervous system disease. CXCL10 over-expression has been observed in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease and HIV-associated dementia. More recent studies by others and us have shown that CXCL10 elicits apoptosis in fetal neurons. The mechanism of(More)
Memory B cells (MBCs) are a key component of long term humoral immunity to many human infectious diseases. Despite their importance, we know little about the generation or maintenance of antigen-(Ag)-specific MBCs in humans in response to infection. A frequently employed method for quantifying Ag-specific MBCs in human peripheral blood (Crotty et al., 2004)(More)
BACKGROUND In experimental models of human and mouse malaria, sterilizing liver stage immunity that blocks progression of Plasmodium infection to the symptomatic blood stage can be readily demonstrated. However, it remains unclear whether individuals in malaria-endemic areas acquire such immunity. METHODS In Mali, 251 healthy children and adults aged 4-25(More)
With the development of the mobile communication technology and P2P, a combination of mobile computing and P2P, MP2P, has revealed its attractions. Compared to traditional P2P, characteristics of MP2P include unreliable connection, limited bandwidth and constrains of mobile devices. Although there have existed some classic lookup protocols for traditional(More)
Web services composition is a crucial aspect of Web services technology, which gives us the opportunity for selecting new services and best suits our needs at the moment. Doing this automatically would require us to compute our criteria for composing candidate services. Our research represent all criteria guiding the selection of the services as constraints(More)
Although data forwarding algorithms are among the first set of the most important issues explored in sensor networks, how to efficiently and reliably deliver sensing data through a large field of sensors remains a research challenge. Multi-path is favorite alternative for sensor networks, as it provides an easy mechanism to distribute traffic and balance(More)
Non-functional requirements (NFRs) are often regarded as the key success factor in building high quality software. However, most of the requirements elicitation methods are centered on discovering functional requirements only. This paper presents a novel NFRs elicitation approach aiming at empowering requirements analysts with a knowledge repository that(More)
Software engineering practitioners often spend significant amount of time and effort to debug. To help practitioners perform this crucial task, hundreds of papers have proposed various fault localization techniques. Fault localization helps practitioners to find the location of a defect given its symptoms (e.g., program failures). These localization(More)