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Resources in a grid are dynamic, heterogeneous, and widely distributed. End users need a simple and efficient way to aggregate and utilize these diverse resources. We introduce a grid middleware called G-JavaMPI, which combines a high-level message passing interface with the Java language to support portable messaging-passing programming in a grid.(More)
Non-functional requirements (NFRs) are often regarded as the key success factor in building high quality software. However, most of the requirements elicitation methods are centered on discovering functional requirements only. This paper presents a novel NFRs elicitation approach aiming at empowering requirements analysts with a knowledge repository that(More)
Chemokines play a key role in the regulation of central nervous system disease. CXCL10 over-expression has been observed in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease and HIV-associated dementia. More recent studies by others and us have shown that CXCL10 elicits apoptosis in fetal neurons. The mechanism of(More)
Access efficiency and energy conservation are two critical performance concerns in a wireless data broadcast system. We propose in this paper a novel parameterized index called the exponential index that has a linear yet distributed structure for wireless data broadcast. Based on two tuning knobs, index base and chunk size, the exponential index can be(More)
Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to malaria immunity, yet little is known about the B-cell biology that underlies the inefficient acquisition of Pf-specific humoral immunity. This year-long prospective study in Mali(More)
BACKGROUND Antibodies that protect against Plasmodium falciparum (Pf) malaria are only acquired after years of repeated infections. The B cell biology that underlies this observation is poorly understood. We previously reported that "atypical" memory B cells are increased in children and adults exposed to intense Pf transmission in Mali, similar to what has(More)
In malaria-naïve individuals, Plasmodium falciparum infection results in high levels of parasite-infected red blood cells (iRBCs) that trigger systemic inflammation and fever. Conversely, individuals in endemic areas who are repeatedly infected are often asymptomatic and have low levels of iRBCs, even young children. We hypothesized that febrile malaria(More)