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Inflammatory mediators play a crucial role in the pathophysiology of several neurodegenerative diseases including acquired immune deficiency syndrome dementia complex. In the present study we identified a link between CXCL10 overexpression in the brain and human immunodeficiency virus dementia and demonstrated the presence of the chemokine CXCL10 and its(More)
Memory B cells (MBCs) are a key component of long term humoral immunity to many human infectious diseases. Despite their importance, we know little about the generation or maintenance of antigen-(Ag)-specific MBCs in humans in response to infection. A frequently employed method for quantifying Ag-specific MBCs in human peripheral blood (Crotty et al., 2004)(More)
BACKGROUND In experimental models of human and mouse malaria, sterilizing liver stage immunity that blocks progression of Plasmodium infection to the symptomatic blood stage can be readily demonstrated. However, it remains unclear whether individuals in malaria-endemic areas acquire such immunity. METHODS In Mali, 251 healthy children and adults aged 4-25(More)
With the development of the mobile communication technology and P2P, a combination of mobile computing and P2P, MP2P, has revealed its attractions. Compared to traditional P2P, characteristics of MP2P include unreliable connection, limited bandwidth and constrains of mobile devices. Although there have existed some classic lookup protocols for traditional(More)
Web services composition is a crucial aspect of Web services technology, which gives us the opportunity for selecting new services and best suits our needs at the moment. Doing this automatically would require us to compute our criteria for composing candidate services. Our research represent all criteria guiding the selection of the services as constraints(More)
Non-functional requirements (NFRs) are often regarded as the key success factor in building high quality software. However, most of the requirements elicitation methods are centered on discovering functional requirements only. This paper presents a novel NFRs elicitation approach aiming at empowering requirements analysts with a knowledge repository that(More)
Resources in a grid are dynamic, heterogeneous, and widely distributed. End users need a simple and efficient way to aggregate and utilize these diverse resources. We introduce a grid middleware called G-JavaMPI, which combines a high-level message passing interface with the Java language to support portable messaging-passing programming in a grid.(More)
Consider a question and its answers in Stack Overflow as a knowledge unit. Knowledge units often contain semantically relevant knowledge, and thus linkable for different purposes, such as duplicate questions, directly linkable for problem solving, indirectly linkable for related information. Recognizing different classes of linkable knowledge would support(More)
The load balance optimization is an important research topic in a replication system, which will affect the performance a lot. Especially in a capacity restricted system, the load balance will be adversely affected by the strategy to replicate the object. In this paper, an algorithm which will calculate the different replication degree based on the(More)
Epidemiological observations in malaria endemic areas have long suggested a deficiency in the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in individuals chronically reinfected with the parasite. Recently, a functionally and phenotypically distinct population of FCRL4(+) hyporesponsive memory B cells (MBCs) was reported to be(More)