Shannon M Stewart

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Insects use taste to evaluate food, hosts, and mates. Drosophila has many "orphan" taste neurons that express no known taste receptors. The Ionotropic Receptor (IR) superfamily is best known for its role in olfaction, but virtually nothing is known about a clade of ∼35 members, the IR20a clade. Here, a comprehensive analysis of this clade reveals expression(More)
Mutations in a human homologue of the yeast DNA mismatch repair gene MSH2 (equivalent to bacterial MutS) cause the condition hereditary non-polyposis colorectal cancer (HNPCC). Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Adenomas are clonal and each may serve as a marker of a single initiating mutation. The progression of(More)
The ampicillin levels in sputum, serum, and saliva from 40 patients receiving a dose of 250 mg., 26 patients receiving a dose of 500 mg., and 11 patients receiving a dose of I g. were estimated. The ampicillin was given orally four times daily. The 1-2 hour and 2-3 hour sputum levels were similar in individual patients. There was no difference in the range(More)
We examine in Drosophila a group of ∼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of the body wall that may be chemosensory. Expression was not(More)
The levels achieved in the sputum by the systemic administration of penicillin have attracted little attention. There are relatively few publications on this subject. The present investigation was designed to find an answer to the following questions: 1. What levels are achieved in the sputum by the systemic administration of penicillin ? 2. Does the sputum(More)
Stewart, Sheila M., Anderson, Isobel M. E., Jones, G. R., and Calder, Margaret A. (1974). Thorax, 29, 110-114. Amoxycillin levels in sputum, serum, and saliva. The levels of amoxycillin in sputum, saliva, and serum from 22 patients were estimated. Fifteen patients had pneumonia and seven had acute exacerbations of chronic bronchitis. The drug was given(More)
The factors associated with exacerbations of chronic bronchitis were investigated in a pilot study of 23 male patients over a period of 29 months. There were 63 exacerbations-56 were fully investigated and in seven only serological studies were possible. Evidence of the presence of an infective agent was sought in the early stages of the exacerbations and(More)