Shannon Eastham

Learn More
PURPOSE To determine clinical and immunologic responses to a multipeptide melanoma vaccine regimen, a randomized phase II trial was performed. PATIENTS AND METHODS Twenty-six patients with advanced melanoma were randomly assigned to vaccination with a mixture of four gp100 and tyrosinase peptides restricted by HLA-A1, HLA-A2, and HLA-A3, plus a tetanus(More)
Many peptide epitopes for cytotoxic T lymphocytes (CTLs) have been identified from melanocytic differentiation proteins. Vaccine trials with these peptides have been limited mostly to those associated with HLA-A2, and immune responses have been detected inconsistently. Cases of clinical regression have been observed after peptide vaccination in some trials,(More)
A melanoma vaccine composed of HLA-A2-restricted peptide YLEPGPVTA (gp100(280)), with or without a modified T-helper epitope from tetanus toxoid AQYIKANSKFIGITEL, has been evaluated in a Phase I trial to assess safety and immunological response. The vaccines were administered s.c. in either of two adjuvants, Montanide ISA-51 or QS-21, to 22 patients with(More)
Purpose: To assess changes in serum cytokine levels in patients treated concomitantly with or without systemic low-dose IL-2. Vaccination targeted CTL responses to peptide antigens, and IL-2 was coadministered to expand activated CTL. Paradoxically, CTL responses were diminished in patients after 2 weeks of IL-2. We hypothesized that changes in the cytokine(More)
To determine if listeners can accurately identify various environmental sounds, a total of 40 sounds, including animal, inanimate, musical, and human sounds, were recorded, randomly arranged on a master tape, and presented to 30 judges for identification. Analysis indicated that, in general, listeners can accurately identify environmental sounds. However,(More)
To determine whether listeners can accurately identify human-imitated animal sounds, 20 speakers (10 females and 10 males) recorded their imitations of cows, cats, dogs, pigs, and sheep. These recordings were randomly arranged on a master tape and presented to 30 judges for identification. Analysis indicates that listeners can accurately identify various(More)
To determine if listeners can accurately distinguish between real and human-imitated animal sounds, a total of 165 recorded sounds (55 real and 110 human-imitated) of cats, cows, dogs, pigs, and sheep were randomly arranged on a master tape and presented to 30 listeners for discriminative judgments. Results indicate that, in general, listeners can(More)
  • 1