Shanglin Zhou

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Dopamine (DA) profoundly modulates excitatory synaptic transmission and synaptic plasticity in the brain. In the present study the effects of SKF83959, the selective agonist of phosphatidylinositol (PI)-linked D(1) -like receptor, on the excitatory synaptic transmission were investigated in rat hippocampus. SKF83959 (10-100 μM) reversibly suppressed the(More)
A series of new aporphine analogues (aporlogues) were synthesized bearing a C-, N-, or O-linkage at the C11 position. Lipoic ester (-)-15 was identified as a full agonist at the dopamine D(2) and serotonin 5-HT(1A) receptors with K(i) values of 174 and 66 nM, respectively. It elicited antiparkinsonian action on Parkinsin's disease (PD) rats with minor(More)
The serotonin receptor subtype 1A (5-HT(1A)R) has been implicated in several neurological conditions, and potent 5-HT(1A)R agonists have therapeutic potential for the treatment of depression, anxiety, schizophrenia, and Parkinson's disease. In the present study, a homology model of 5-HT(1A)R was built based on the latest released high-resolution crystal(More)
Prior odor experience has a profound effect on the coding of new odor inputs by animals. The olfactory bulb, the first relay of the olfactory pathway, can substantially shape the representations of odor inputs. How prior odor experience affects the representation of new odor inputs in olfactory bulb and its underlying network mechanism are still unclear.(More)
Odor responses of mitral cells in the olfactory bulb are observed to be sparse spatially and decorrelated in response to odor signals [1]. We have built a large scale biophysical network model of olfactory bulb composed of mitral and granule cells, corresponding to 1/100th of the real system in the rat, and used direct experimental imaging data of glomeruli(More)
Experiments have demonstrated that cortical and sensory neurons prefer to response to signals with characteristics of long-term correlation or 1/f noise feature better than signals with no correlation like white-noise-type [1]. In order to study the underlying mechanism, we built up a cortical neuronal model [2] based on Hodgkin-Huxley theory to study the(More)
AIM 3-Methyl-6-chloro-7,8-hydroxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF83959) have been shown to affect several types of voltage-dependent channels in hippocampal pyramidal neurons. The aim of this study was to determine how modulation of a individual type of the channels by SKF83959 contributes to the overall excitability of CA1(More)
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