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Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa.
TLDR
The structures of 1-3 gyrosanols A-C were elucidated through extensive spectroscopic analyses and exhibited antiviral activity against HCMV with IC(50)'s of 2.6 and 3.7 microM, respectively. Expand
Human Cytomegalovirus UL76 Encodes a Novel Virion-Associated Protein That Is Able To Inhibit Viral Replication
TLDR
Evidence indicated that expression of pUL76 at the immediate-early phase of the viral replication cycle leads to the inhibition of HCMV production, which may provide a novel mechanism for the resumption of latency. Expand
Xenia diterpenoids from the formosan soft coral Xenia blumi.
TLDR
Eight new xenia diterpenoids were isolated from the methylene chloride solubles of the Formosan soft coral Xenia blumi and their cytotoxicity against selected cancer cells was measured in vitro. Expand
Human cytomegalovirus UL76 induces chromosome aberrations
TLDR
These findings suggest that the virus-associated protein UL76 induces DNA damage and the accumulation of chromosome aberrations in infected cells. Expand
Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni.
TLDR
Three new cytotoxic steroids and two ylangene-type sesquiterpenoids, lemnalol and the new compound cervicol, as well as three ylangenes, isolemnall and 4-oxo-alpha-ylangene, were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Expand
New anti-inflammatory 4-methylated steroids from the Formosan soft coral Nephthea chabroli
TLDR
Eight new 4-methylated steroids, nebrosteroids A-H (1-8) were isolated from the acetone solubles of the Formosan soft coral Nephthea chabroli by extensive NMR spectroscopic analysis and their anti-inflammatory activity was measured in vitro. Expand
New cytotoxic constituents from the Formosan soft corals Clavularia viridis and Clavularia violacea.
TLDR
Three new cytotoxic prostanoids, claviridenone E-G, and three new cytOToxic steroids, stoloniferone E -G, were isolated from the methylene chloride solubles of the Formosan soft coral Clavulariaviridis and their cytotoxicity against selected cancer cells was measured in vitro. Expand
Revision of the Absolute Configuration at C(23) of Lanostanoids and Isolation of Secondary Metabolites from Formosan Soft Coral Nephthea erecta
TLDR
The cytotoxicities against selected cancer cells and the anti-inflammatory effects of these tested metabolites 1-7 were determined in vitro. Expand
Capnellenes from the Formosan soft coral Capnella imbricata.
TLDR
Three anti-inflammatory sesquiterpenes were isolated from the acetone/methylene chloride extracts of the Formosan soft coral Capnella imbricata and the structures of these compounds were elucidated by extensive spectroscopic analysis. Expand
Human Cytomegalovirus UL76 Elicits Novel Aggresome Formation via Interaction with S5a of the Ubiquitin Proteasome System
TLDR
It is demonstrated that UL76 induces a novel nuclear aggresome, likely by subverting S5a of the UPS, which is a major receptor of polyubiquitinated proteins for UPS proteolysis via its conserved region and the von Willebrand factor type A (VWA) domain of S5A. Expand
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