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Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA
Within the base excision repair (BER) pathway, the DNA N-glycosylases are responsible for locating and removing the majority of oxidative base damages. Endonuclease III (Nth), formamidopyrimidine DNAExpand
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Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va
Significance Intracellular cargo transport is carried out by ensembles of cytoskeleton-based molecular motors, such as myosin Va. Physiologically, motor molecules are bound to (and mechanicallyExpand
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Random walk of processive, quantum dot-labeled myosin Va molecules within the actin cortex of COS-7 cells.
Myosin Va (myoVa) is an actin-based intracellular cargo transporter. In vitro experiments have established that a single myoVa moves processively along actin tracks, but less is known about how thisExpand
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Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose
For pancreatic β-cells to secrete insulin in response to elevated blood glucose, insulin granules retained within the subplasmalemmal space must be transported to sites of secretion on the plasmaExpand
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Distinct contributions of model MaSp1 and MaSp2 like peptides to the mechanical properties of synthetic major ampullate silk fibers as revealed in silico.
All characterized major ampullate silks from orb-web weaving spiders are composites of primarily two different proteins: MaSp1 and MaSp2. The conserved association of MaSp1 and MaSp2 in these spiderExpand
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Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion
BackgroundApicomplexan parasites employ a unique form of movement, termed gliding motility, in order to invade the host cell. This movement depends on the parasite’s actomyosin system, which isExpand
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Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments
The survival of Toxoplasma gondii within its host cell requires protein release from vesicles, called dense granules (DGs). Through imaging of the motions of DGs in live intracellular parasites, itExpand
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SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS
Skeletal muscle myosin-binding protein C (MyBP-C) is a myosin thick filament-associated protein; localized through its C terminus to distinct regions (C-zones) of the sarcomere. MyBP-C modulatesExpand
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An investigation of the divergence of major ampullate silk fibers from Nephila clavipes and Argiope aurantia.
The major ampullate fiber of both Nephila clavipes and Argiope aurantia is composed of two different proteins, MaSp1 and MaSp2. Each of these proteins has a highly conserved pattern ofExpand
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Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
Intracellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell's three-dimensional (3D) highway of actin filaments. At actin filament intersections, theExpand
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