Shan Song

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Isoflurane is a commonly used inhaled anesthetic, which induces apoptosis of SH‑SY5Y cells in a dose‑ and time‑dependent manner; however, the underlying mechanisms remain unknown. The authors of the present study hypothesized that a mutation in β‑amyloid precursor protein (APP), which is a gene associated with familial Alzheimer's disease, may render cells(More)
A hierarchical clustering genetic algorithm which used hierarchical clustering based fitness sharing method was designed. Special designed inner-species selection and inner-species/inter-species crossover are used to improve the search ability. The results of several benchmark problems show that this algorithm is quite effective at the optimization of(More)
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