Shamik Ghosh

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Type II alveolar epithelial cells (AEC) can produce various antimicrobial and proinflammatory effector molecules. This, together with their abundance and strategic location, suggests a role in host defense against pulmonary pathogens. We report that murine type II AEC, like their human counterparts, express class II major histocompatibility complex (MHC).(More)
Apolipoprotein E-deficient (ApoE-/-) mice develop atherosclerotic lesions throughout the arterial tree, including the carotid bifurcation. Although the expression of adhesion molecules such as ICAM-1, vascular cell adhesion molecule-1 (VCAM-1), and P-selectin on endothelium that overlie atherosclerotic plaques has been implicated in monocyte recruitment to(More)
Transforming growth factor-beta (TGF-beta) is an important regulator of development. In vitro, TGF-beta is secreted in a latent, inactive form and can be activated by pH extremes, chaotropic agents, or cell-surface proteases. However, there is little evidence for the existence of latent TGF-beta in vivo. In this study, we determined whether (1) cultured(More)
Host immunity to Mycobacterium tuberculosis is mediated by T cells that recognize and activate infected macrophages to control intracellular bacterial replication. The early appearance of T cells in the lungs of infected mice correlates with greater resistance to infection. However, it is unknown whether the trafficking of T cells to the lung following(More)
The power graph of a group is the graph whose vertex set is the group, two elements being adjacent if one is a power of the other. We observe that nonisomorphic finite groups may have isomorphic power graphs, but that finite abelian groups with isomorphic power graphs must be isomorphic. We conjecture that two finite groups with isomorphic power graphs have(More)
Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown. Here, we demonstrate that Notch3 is expressed selectively in pulmonary artery VSMCs, is activated from late fetal to early(More)