Shalini Malhotra

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The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett's esophagus and EAC samples, together with one in-depth Barrett's esophagus case study sampled over time and space, we have provided the following new insights: (i)(More)
A 29 year old primigravida patient admitted to Al Qassimi Hospital for induction of labor at 34 wks due to mild pre-eclampsia. She then went on to develop dyspnea. After a multidisciplinary approach in conjunction with obstetricians, anesthetists and cardiologists the patient was diagnosed as having Eisenmenger syndrome. She was managed in accordance with(More)
History A 30-year-old man presented to the emergency department with epigastric pain. He was vomiting and in distress, and he had a history of thalassemia. Physical examination findings were unremarkable. Pertinent blood results were a hemoglobin level of 10.5 g/dL (6.52 mmol/L) (normal range, 13.5-18.0 g/dL [8.38-11.17 mmol/L]) and a bilirubin level of 62(More)
Cohort study: Risk stratification of Barrett’s oesophagus using a non-endoscopic sampling method coupled with a biomarker panel Caryn S Ross-Innes*, PhD, Hamza Chettouh*, PhD, Achilleas Achilleos*, PhD, Nuria Galeano-Dalmau, MSc, Irene Debiram-Beecham, MSc, Shona MacRae, PhD, Petros Fessas, BA, Elaine Walker, BSc, Sibu Varghese, PhD Theodore Evan, MBBChir,(More)
Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid(More)
The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are esophageal squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomarker analysis could reduce the subjectivity associated with histologic assessment of dysplasia and thus improve(More)
New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a 55-year-old male with OAC without recombinant-DNA transformation. Somatic genetic variations from MFD-1, tumour, normal oesophagus, and(More)
BACKGROUND Barrett's oesophagus predisposes to adenocarcinoma. However, most patients with Barrett's oesophagus will not progress and endoscopic surveillance is invasive, expensive, and fraught by issues of sampling bias and the subjective assessment of dysplasia. We investigated whether a non-endoscopic device, the Cytosponge, could be coupled with(More)
Tuberculosis is a common opportunistic infection and a leading cause of death in HIV patients worldwide, especially in developing countries. The study was conducted to evaluate the relation of CD4 counts to occurrence and type of TB and to observe for the recovery of CD4 counts after treatment for tuberculosis in patients of pulmonary tuberculosis and extra(More)
This study was designed to identify significant differences in gene expression profiles of human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinomas (OPSCC) and to better understand the functional and biological effects of HPV infection in the premalignant pathway. Twenty-four consecutive patients with locally advanced(More)