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Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett'sExpand
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Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium
Summary We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequentialExpand
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Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study.
BACKGROUND Barrett's oesophagus predisposes to adenocarcinoma. However, most patients with Barrett's oesophagus will not progress and endoscopic surveillance is invasive, expensive, and fraught byExpand
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Pleomorphic appearance in Mycobacterium tuberculosis.
Mycobacterium tuberculosis still remains a substantial global threat due to ill defined mechanisms that enable this organism to persist and replicate. Although molecular methods have revolutionizedExpand
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Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Continual evolution of cancer makes it challenging to predict clinical outcomes. Highly varied and unpredictable patient outcomes in esophageal adenocarcinoma (EAC) prompted us to question theExpand
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Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18Expand
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