Shalini Chouhan

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The present study has been carried on changes in activity of alkaline phosphatase in serum and gastrocnemius muscle of mice after sub-chronic use of diclofenac. Mice in experimental group received diclofenac (10 mg/kg body wt /day) for 30 days while control group received normal saline. Alkaline phosphatase was assayed in muscle and serum and its activity(More)
Diclofenac sodium is known to interfere with renal physiology by inhibiting prostaglandins. Previous studies indicate that various nephrotoxins damage proximal renal tubules by altering alkaline phosphatase (APase) activity. APase has been reported to be a function related marker in renal proximal tubular epithelia where it is highly expressed. Present(More)
The present investigation was undertaken to study the effect of diclofenac sodium on alkaline phosphatase and acid phosphatase activity in mice tibiae. Diclofenac was administered at the dose rate of 10 mg/kg body wt/day intramuscularly to experimental animals for 10, 20 and 30 days while the control group received normal saline. Alkaline phosphatase and(More)
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