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The incidence of type 2 diabetes mellitus is increasing worldwide. The existing therapeutic classes of antidiabetic drugs are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination. One emerging novel therapeutic class of antidiabetic drugs is sodium glucose cotransporter 2 (SGLT2) inhibitors.(More)
OBJECTIVE To compare and study the dipeptidy1 peptidase-4 (DPP-4) inhibitors in combination with metformin against established combination therapies. MATERIALS AND METHODS This 16-week study was designed to compare sitagliptin versus pioglitazone as add-on therapy in patients of type 2 diabetes mellitus inadequately controlled with metformin alone.(More)
OBJECTIVE To evaluate antidepressant-like effect of tramadol in mice. MATERIALS AND METHODS Tramadol was administered at three different doses (10, 20, and 40 mg/kg, i.p.) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug-treated mice was recorded in forced swim test (FST). The antidepressant effect of(More)
IMPORTANCE OF THE FIELD Acquired immunodeficiency syndrome (AIDS) is one of the leading causes of death worldwide. Although the combination therapies of highly active antiretroviral therapy (HAART) have significantly contributed to virological suppression, improved immune function and quality of life, issues such as tolerability, drug-drug interactions and(More)
The study was undertaken to evaluate physical, psychological and functional aspects in quality of life (QoL) assessment prospectively in biopsy-proven head and neck cancer patients receiving radical radiotherapy. Fifty male patients were assessed using Karnofsky's Performance Status (KPS), Beck's Depression Inventory (BDI) and the Functional Living Index –(More)
OBJECTIVE To prospectively evaluate sexual function in women who underwent surgery for incontinence and/or prolapse using the Pelvic Organ Prolapse-Urinary Incontinence Sexual Questionnaire (PISQ), and to provide a preliminary evaluation of the PISQ's psychometric properties for a population of women in the United Kingdom. METHODS Women who underwent(More)
OBJECTIVE To evaluate antidepressant like effect of tramadol in mice. MATERIALS AND METHODS Tramadol was administered at three different doses (10,20 and 40 mg/kg, i.p) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug treated mice were recorded in tail suspension test (TST).The antidepressant effect of(More)
Reports on advice about exercise for women with hypertensive disorders of pregnancy are reviewed and how exercise could influence long-term cardiovascular risk is assessed. Exercise in pregnancy seems to be beneficial in pregnancies complicated by hypertension. However, the intensity of the exercise to be recommended remains unclear. Further research is(More)