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Structural and Functional Analyses of a Novel Ig-like Cell Adhesion Molecule, hepaCAM, in the Human Breast Carcinoma MCF7 Cells*
TLDR
The cytoplasmic domain of hepaCAM is essential to its function on cell-matrix interaction and cell motility, and is shown to co-localize with E-cadherin at the lateral membrane. Expand
Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma.
TLDR
Gene hepaCAM, frequently silenced in HCC, encodes an Ig-like transmembrane glycoprotein and is involved in cell adhesion and growth control. Expand
The roles of cell adhesion molecules in tumor suppression and cell migration
TLDR
Paradoxically, in 2005, an immunoglobulin superfamily cell adhesion molecule hepaCAM was identified that is able to suppress cancer cell growth and yet induce migration, and CEACAM1 was verified to co-function as a tumor suppressor and invasion promoter. Expand
HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells.
TLDR
The data show that HEPN1 is frequently silenced in HCC, and that exogenous H EPN1 exhibits antiproliferative effect on HepG2 cells, suggesting that silencing of HEPn1 may be associated with carcinogenesis of hepatocytes. Expand
Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells.
TLDR
The results suggest that the expression of hepaCAM in MCF7 cells not only inhibits cell growth but also induces cellular senescence through the p53/21 pathway. Expand
A robust high-throughput sandwich cell-based drug screening platform.
TLDR
The hepatocytes exhibited improved drug sensitivity and low variability in hepatotoxicity responses amongst cells transferred from different dates of perfusion culture, which enables robust high-throughput screening of drug candidates. Expand
HepaCAM induces G1 phase arrest and promotes c‐Myc degradation in human renal cell carcinoma
TLDR
It is demonstrated that re‐expression of hepaCAM can cause an accumulation in G0/G1 phase in 786‐0 cells and implies that the decrease in c‐Myc protein expression, resulting from ectopic expression of hePACAM, may contribute to the inhibition of proliferation in these cells. Expand
Cell-delivery therapeutics for liver regeneration.
TLDR
There is a switch-like regulation of liver regeneration that changes state according to a stimulus threshold of extracellular influences such as cytokines, matrices and neighboring cells, which will impact future choices of cell sources, delivery vehicles, and sites of cell transplantation. Expand
The immunoglobulin‐like cell adhesion molecule hepaCAM modulates cell adhesion and motility through direct interaction with the actin cytoskeleton
TLDR
It is found that hepaCAM was partially insoluble in Triton X‐100 and colocalized with the actin cytoskeleton on the plasma membrane and deletion of either the extracellular or the cytoplasmic domain of he PaCAM abolished actin coprecipitation as well as delayed cell–ECM adhesion and cell motility. Expand
Rapid construction of mechanically- confined multi- cellular structures using dendrimeric intercellular linker.
TLDR
This work demonstrates rapid assembly of C3A cells into multi- cell structures using a dendrimeric intercellular linker and constructed defined multi- cellular structures such as rings, sheets or branching rods that can serve as potential tissue building blocks to be further assembled into complex 3D tissue constructs for biomedical applications. Expand
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