Shaikh Mohammad

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A series of novel aryl aminosulfonamides was designed and synthesized as 5-HT(6) receptor ligands. Many compounds screened in a functional reporter gene based assay displayed potent antagonistic activity with Kb values in the range of 0.02-10nM. The lead compound 11m exemplified in this series showed good ADME surrogate properties, acceptable(More)
e13545 Background: A recent study from our lab demonstrated that simvastatin induces apoptosis in prostate cancer cells and inhibit proliferation, invasion, and tumor formation in vivo via inhibition of Akt pathway (Kochuparambil et al, J Pharm Exp Ther, 2011). METHODS In the current study we investigated the molecular mechanisms by which simvastatin (SN)(More)
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