Shaheen Rasheed

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The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARδ and offer the opportunity to revisit the controversial role of PPARδ in carcinogenesis (several papers report that PPARδ either promotes or inhibits cancer). This review summarizes the pharmacology of NO-NSAIDs, PPARδ cancer biology, and the relationship(More)
A class of novel N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-substituted sulfonamide 3(a-f) and methyl (2'-(1Htetrazol-5-yl)biphenyl-4-yl)-substituted carbamate 5(a-d) derivatives were synthesized from (2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine, an important drug intermediate and using pharmacologically active functionalized sulfonyl chlorides and(More)
D-RNAi (Messenger RNA-antisense DNA interference), a novel posttranscriptional phenomenon of silencing gene expression by transfection of mRNA-aDNA hybrids, was originally observed in the effects of bcl-2 on phorbol ester-induced apoptosis in human prostate cancer LNCaP cells. This phenomenon was also demonstrated in chicken embryos and a human CD4(+) T(More)
We have characterized various biologic, immunologic and growth properties of several cell lines established from a spontaneous rat sarcoma that was discovered more than 60 yr ago. The tumors consisted of mixed cell types with no detectable host cellular immune response. Cultures derived from single-cell clones of the parental cell line were non-invasive but(More)
Human tumor cell lines, a rhabdomyosarcoma (RD), and a fibrosarcoma (HT-1080) were distinguished from normal human fibroblasts by tumorigenicity in athymic nude mice and immunosuppressed rats and hamsters, secretion of different types of collagen and procollagen molecules, and reduced amounts of fibronectin. The fibronectins secreted by both normal and(More)
The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARdelta and offer the opportunity to revisit the controversial role of PPARdelta in carcinogenesis (several papers report that PPARdelta either promotes or inhibits cancer). This review summarizes the pharmacology of NO-NSAIDs, PPARdelta cancer biology, and the(More)
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