Shahana Urooj Kazmi

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INTRODUCTION The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different(More)
BACKGROUND Hepatitis B virus (HBV) is an etiological agent of acute and chronic liver disease existing throughout the world. The high genetic variability of HBV genome is reflected by eight genotypes (A to H), and each genotype has characteristic geographical distribution, which is important epidemiologically. Previous studies from the province of Sindh,(More)
BACKGROUND This study was conducted to examine the frequency of contamination in retail meat available in Karachi, Pakistan. METHODOLOGY Raw meat samples (250) and surface swabs (90) from meat processing equipment and the surrounding environment were analyzed for microbiological contamination. RESULTS Out of 340 samples, 84% were found to be(More)
AIM To determine antibiotic resistance of Helicobacter pylori (H. pylori) in Pakistan and its correlation with host and pathogen associated factors. METHODS A total of 178 strains of H. pylori were isolated from gastric biopsies of dyspeptic patients. Susceptibility patterns against first and second-line antibiotics were determined and trends of(More)
An animal model resembling the human disease caused byCampylobacter jejuni has been developed. Characteristic illness followed intragastric challenge of neonatal mice with strains ofC. jejuni enhanced for virulence by serial intraperitoneal passage in weanling mice of organisms suspended in either mucin or iron dextran. Such passage lowered the LD50 in(More)
OBJECTIVE To determine the pattern of antibiotic resistance in the clinical isolates of Staphylococcus (S.) aureus, Methicillin Resistant S. aureus (MRSA) and define the possible emergence of Vancomycin resistant S. aureus (VRSA) in Karachi. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY Essa Laboratories and Department of Molecular(More)
BACKGROUND We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source. METHODS Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIV-positive IDU samples. (More)
BACKGROUND Prevalence of Helicobacter pylori (H. pylori) infection is an increasing problem in developing countries. Several environmental factors such as overcrowding, poverty, contaminated drinking water and food are considered to contribute toward transmission of infection; however, little is known about their definitive roles. The aim of this study is(More)
Synergistic combinations of antimicrobial agents with different mechanisms of action have been introduced as more successful strategies to combat infections involving multidrug resistant (MDR) bacteria. In this study, we investigated synergistic antimicrobial activity of Camellia sinensis and Juglans regia which are commonly used plants with different(More)
OBJECTIVE To determine the frequency and susceptibility pattern of multi-drug resistant (MDR) Pseudomonas aeruginosa isolated from clinical specimens in Karachi. METHODS This cross sectional study was conducted in Microbiology Department, University of Karachi, from January 2012 to January 2013. Clinical specimens were collected from different hospitals(More)