Shafinaz Akhter

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Intestinal development in amniotes is driven by interactions between progenitor cells derived from the three primary germ layers. Genetic analyses and gene targeting experiments in zebrafish offer a novel approach to dissect such interactions at a molecular level. Here we show that intestinal anatomy and architecture in zebrafish closely resembles the(More)
Midkine (MK) is a heparin-binding growth factor that has been implicated in neural survival and differentiation, fibrinolysis, and carcinogenesis. It is expressed in the nervous system during early Xenopus development. In the present study, we demonstrated that injection of vegetal blastomeres with Xenopus MK at the 8-cell stage results in incomplete(More)
The removal of N-terminally located clusters of basic amino acids (N-tail) or C-terminally located clusters of basic amino acids (C-tail) from the midkine (MK) molecule severely reduced its neurite-promoting activity. However, experiments involving chemically synthesized MK derivatives revealed that the roles of the N-tail and C-tail were mostly indirect(More)
Cavet, Megan E., Shafinaz Akhter, Fermin Sanchez De Medina, Mark Donowitz, and Chung-Ming Tse. Na1/H1 exchangers (NHE1–3) have similar turnover numbers but different percentages on the cell surface. Am. J. Physiol. 277 (Cell Physiol. 46): C1111–C1121, 1999.—NHE1, NHE2, and NHE3 are well-characterized cloned members of the mammalian Na1/H1 exchanger (NHE)(More)
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