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This paper considers a clustering method motivated by a multivariate analysis of variance model and computationally based on eigenanalysis (thus the term " spectral " in the title). Our focus is on large problems, and we present the method in the context of clustering genes using microarray expression data. We provide an eecient computational algorithm and(More)
Systolic blood pressure (SBP) is an age-dependent complex trait for which both environmental and genetic factors may play a role in explaining variability among individuals. We performed a genome-wide scan of the rate of change in SBP over time on the Framingham Heart Study data and one randomly selected replicate of the simulated data from the Genetic(More)
The objective of the present study was to characterize the consumption of cooked oatmeal in the United States (U.S.) and to determine whether oatmeal consumption is associated with body mass index (BMI). To estimate current intakes of cooked oatmeal in the various age and gender population groups, we used dietary intake data from Day 1 of the U.S. 2009-2010(More)
Optimizing heath care services for seniors in emergency departments (ED) is a core component of the " Senior Friendly Hospital Approach " being implemented in Quebec. We measured the availability of geriatric expertise in Quebec EDs and its relationship with ED characteristics such as university affiliation, number of stretchers, and geographical location.(More)
Background Information: Limited research has suggested that rural residents are at increased risk of dementia. Objective: The objective of this study is to determine if rural residence is associated with dementia using both cross-sectional and prospective analyses. Methods: In 1991, 1763 community-dwelling adults aged 65+ participated in the Manitoba Study(More)
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