Shady Younis

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The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of(More)
The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling components, providing genetic evidence for a role in the PI3K(More)
ZBED6 is a recently discovered transcription factor, unique to placental mammals, that has evolved from a domesticated DNA transposon. It acts as a repressor at the IGF2 locus. Here we show that ZBED6 acts as a transcriptional modulator in mouse myoblast cells, where more than 700 genes were differentially expressed after Zbed6-silencing. The most(More)
Younis, S. 2017. Functional characterization of the biological significance of the ZBED6/ ZC3H11A locus in placental mammals. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1372. 57 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0072-6. The recent advances in molecular and computational biology have made(More)
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