Shabnam Sabetkish

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To report the results of whole liver decellularization by two different methods. To present the results of grafting rat and sheep decellularized liver matrix (DLM) into the normal rat liver and compare natural cell seeding process in homo/xenograft of DLM. To compare the results of in vitro whole liver recellularization with rats' neonatal green fluorescent(More)
OBJECTIVE To demonstrate the feasibility, cosmetic outcome and therapeutic values of our single incisional approach in patients with both hypospadias and inguinal hernia (IH) in comparison with standard multiple incisional techniques. MATERIALS AND METHODS Sixty hypospadias-IH repairs were performed from February 2005 to February 2012. These patients were(More)
To compare the biocompatibility and histological aspects of cholecyst-derived extra cellular matrix (CDECM) graft, either alone or with application of autologous detrusor muscles small fragments (ADMSF) on rabbit bladder mucosa for bladder augmentation. The gallbladders were acellularized and evaluated for preserved acellular matrix scaffold and biophysical(More)
OBJECTIVE To investigate the feasibility of a new approach for cystoplasty using autologous smooth muscle cell (SMC) sheet and scaffold-less bladder tissue engineering with the main focus on histological outcomes in a rabbit model. MATERIALS AND METHODS In all, 24 rabbits were randomly divided into two groups. In the experimental group, SMCs were obtained(More)
We used a rat model to decellularize and seed alveolar cells on a three-dimensional lung scaffold to preserve alveolar microarchitecture. We verified the preservation of terminal respiratory structure by casting and by scanning electron microscopy (SEM) of the casts after decellularization. Whole lungs were obtained from 12 healthy Sprague-Dawley rats,(More)
To investigate the outcomes of implanting rat decellularized trachea scaffold (DTS) between the paravertebral muscles of nude mice using the body as a bioreactor for total graft recellularization. The tracheas of four rats were aseptically resected and decellularized. To assess the efficiency of the decellularization procedure, all decellularized scaffolds(More)
PURPOSE The aim of this study was to produce a decellularized rabbit vermiform appendix (sacculus rotundus) and investigate its feasibility in bladder augmentation or appendicovesicostomy. The superiority of sacculus rotundus over other tissues is its unique mechanical properties as well as its abundant collagen content. MATERIALS AND METHODS The(More)
To introduce the role of fibrin sealant and preputial acellular matrix (PAM) as a new source of inert collagen matrix for urethral reconstruction. A ventral urethral segmental defect was created in 24 male rabbits divided into four groups. In group 1 (G1), urethrotomy was closed in layers. In group 2 (G2), closure was followed by applying fibrin sealant. In(More)
PURPOSE To determine the best method for decellularisation of aortic valve conduits (AVCs) that efficiently removes the cells while preserving the extracellular matrix (ECM) by examining the valvular and conduit sections separately. MATERIAL/METHODS Sheep AVCs were decellularised by using three different protocols: detergent-based (1% SDS+1% SDC),(More)
OBJECTIVE Lack of appropriate approaches that reliably predict response of Wilms' tumor (WT) to anticancer agents remains a major deficiency in clinical practice of individualized cancer therapy. The aim of this study was to establish a patient-derived tumor tissue (PDTT) xenograft model of WT for individualized chemotherapeutic regimen selection in(More)