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  • Haruhisa Inoue, Ling Lin, +10 authors O. Isacson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 4 September 2007)
  • The nervous system-specific leucine-rich repeat Ig-containing protein LINGO-1 is associated with the Nogo-66 receptor complex and is endowed with a canonical EGF receptor (EGFR)-like tyrosineContinue Reading
  • Robert H Miller, Sha Mi
  • Medicine
  • Nature Neuroscience
  • 2007
  • The loss of central nervous system myelin and the failure of remyelination by oligodendrocytes contribute to the functional impairment that characterizes diseases such as multiple sclerosis. WhyContinue Reading
  • Qing-ling Fu, Bing Hu, Wutian Wu, Robert B. Pepinsky, Sha Mi, Kwok-fai So
  • Medicine
  • Investigative ophthalmology & visual science
  • 2008 (First Publication: 1 March 2008)
  • PURPOSE LINGO-1 is a functional member of the Nogo66 receptor (NgR1)/p75 and NgR1/TROY signaling complexes that prevent axonal regeneration through RhoA in the central nervous system. LINGO-1 alsoContinue Reading