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Many long non-coding RNA (lncRNA) genes identified in mammals have multiple exons and functional domains, allowing them to bind to polycomb proteins, DNA methyltransferases, and specific DNA sequences to regulate genome methylation. Little is known about the origin and evolution of lncRNAs. ANRIL/CDKN2B-AS consists of 19 exons on human chromosome 9p21 and(More)
BACKGROUND An increasing number of long noncoding RNAs (lncRNAs) have been identified recently. Different from all the others that function in cis to regulate local gene expression, the newly identified HOTAIR is located between HoxC11 and HoxC12 in the human genome and regulates HoxD expression in multiple tissues. Like the well-characterised lncRNA Xist,(More)
MOTIVATION In mammalian cells, many genes are silenced by genome methylation. DNA methyltransferases and polycomb repressive complexes, which both lack sequence-specific DNA-binding motifs, are recruited by long non-coding RNA (lncRNA) to specific genomic sites to methylate DNA and chromatin. Increasing evidence indicates that many lncRNAs contain(More)
In this paper, we discuss the economic reasons for overexploitation that led to the Bohai Gulf oil spill, using game theory. Based on the Bohai Gulf incident, we present the causes of ocean international petroleum cooperation, reveal the connection between the interests of Chinese local oil companies and that of a foreign oil company, analyze both sides of(More)
Strains of Lactobacillus bulgaricus and Angel Yeast were combined to ferment raw pork and make pork jerky. After fermentation, the jerky was dried and then tested for sensory evaluation, pH and free amino acid content. The results showed that the optimal conditions for fermentation using L. bulgaricus and Angel Yeast were: a pH of 6.5, a 1:1 (v/v) ratio of(More)
Taking the theses’ keywords in China from 1986 to 2014 as the research materials, use the basis concept of the Big Data Theory to further study the keywords which related to oil and gas industry. Analyze the keywords frequency of the theses in oil and gas industry and its co-occurrence frequency pair, and then use the theory of mapping knowledge domain to(More)
Let d ≥ 1, ∈ Z m are fixed, distinct and nonzero real numbers. We show that the m-(sub)linear version below of the Ratnakumar and Shrivastava [11] Littlewood-Paley square function f 1 (x − θ 1 y) · · · f m (x − θ m y)e 2πii·y K(y)dy| 2 1/2 is bounded from L p1 (R d) × · · · × L pm (R d) to L p (R d) when 2 ≤ p i < ∞ satisfy 1/p = 1/p 1 + · · · + 1/p m and 1(More)
The purpose of this study is to assess the variance and error in nodule diameter measurement associated with variations in nodule-slice position in cross-sectional imaging. A computer program utilizing a standard geometric model was used to simulate theoretical slices through a perfectly spherical nodule of known size, position, and density within a(More)
BACKGROUND Nonsyndromic orofacial clefts (NSOCs) are the most common craniofacial birth defects with complex etiology in which multiple genes and environmental exposures are involved. Bone morphogenetic protein 7 (BMP7), as a member of the transforming growth factor-beta (TGF-beta) superfamily, has been shown to play crucial roles in palate and other(More)
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