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  • Anutosh Chakraborty, Michael A. Koldobskiy, Nicholas T. Bello, Micah Maxwell, James J. Potter, Krishna R. Juluri +9 others
  • 2010
The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities. We now report that IP7 is a physiologic inhibitor of Akt, a serine/threonine kinase that regulates glucose homeostasis and protein translation, respectively, via the GSK3β and(More)
  • Michelle S. Mazei-Robison, Ja Wook Koo, Allyson K. Friedman, Carien S. Lansink, Alfred J. Robison, Monika Vinish +15 others
  • 2011
While the abuse of opiate drugs continues to rise, the neuroadaptations that occur with long-term drug exposure remain poorly understood. We describe here a series of chronic morphine-induced adaptations in ventral tegmental area (VTA) dopamine neurons, which are mediated via downregulation of AKT-mTORC2 (mammalian target of rapamycin complex-2). Chronic(More)
Inositol phosphates (IPs) act as signaling messengers to regulate various cellular processes such as growth. Inositol polyphosphate multikinase (IPMK) generates inositol tetrakis- and pentakisphosphates (IP₄ and IP₅), acting as a key enzyme for inositol polyphosphate biosynthesis. IPMK was initially discovered as an essential subunit of the arginine-sensing(More)
L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR(More)
Social TV is defined as real-time backchannel communication on social networking sites (SNSs) during a live television broadcast. Despite some pessimistic forecasts concerning the impact of social TV on viewing behaviors, broadcasters have found that the social TV phenomenon plays a positive role in boosting television ratings. We examine whether television(More)
Inositol pyrophosphates such as 5-diphosphoinositol pentakisphosphate (5-IP7) are highly energetic inositol metabolites containing phosphoanhydride bonds. Although inositol pyrophosphates are known to regulate various biological events, including growth, survival, and metabolism, the molecular sites of 5-IP7 action in vesicle trafficking have remained(More)
The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly(More)
[Purpose] The purpose of this study was to investigate the effect of cognitive rehabilitation including tasks of cognitive training on performance of everyday activities in elderly people with early-stage Alzheimer's disease. [Subjects and Methods] Forty-three elderly people (15 men, 28 women) with a diagnosis of Alzheimer's disease who had a Mini-Mental(More)
This paper presents a new lossless color image compression algorithm, based on the hierarchical prediction and context-adaptive arithmetic coding. For the lossless compression of an RGB image, it is first decorrelated by a reversible color transform and then Y component is encoded by a conventional lossless grayscale image compression method. For encoding(More)