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INTRODUCTION Despite the large number of scales to assess cognitive function, these are rarely used in clinical practice, both because of the time they require and because they do not give useful information to the clinician. The aim of this article is to present the characteristics and psychometric properties of a scale which aims, with its simplicity of(More)
OBJECTIVE To review the pharmacological basis of antidepressant potentiation in combination therapy and the clinical evidence for its efficacy. METHOD Literature searches were undertaken and the results reviewed. RESULTS Treatment-resistant depression is common (15-30%). Various strategies exist for dealing with resistant depression, including(More)
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P. falciparum populations and to assess the risk of the possible spread of these parasites outside Pailin, a new epidemiological tool(More)
OBJECTIVE To review the current literature on the use of combinations of antidepressive agents. METHOD Literature searches were undertaken and reviewed on the use of combinations of antidepressants. RESULTS Data sources included surveys, analyses of prescription records, decision algorithms, clinical reports, and studies comparing the monotherapy with(More)
OBJECTIVE The present study uses the data from a large survey conducted to examine the general practice of Spanish psychiatrists on the use of antidepressant combinations in the treatment of depressive disorders. METHOD The sample was drawn from specialists and psychiatric residents practicing in Spain who were respondents to a questionnaire distributed(More)
OBJECTIVE To review the neuropharmacological basis of antidepressant combination therapy. METHOD Literature searches and other relevant material were obtained and reviewed. RESULTS The overall clinical aim of combining antidepressants is to increase the efficacy whilst minimizing the side effects. Although such prescriptions are frequently based on the(More)
OBJECTIVE To evaluate the treatment options in patients who do not respond appropriately to a single antidepressant alone. METHOD The medical literature was reviewed. RESULTS A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug.(More)
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