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  • G. Bora-Tatar, D. Dayangaç-Erden, A. Demir, S. Dalkara, K. Yelekçi, H. Erdem-Yurter
  • Medicine, Chemistry
  • Bioorganic & medicinal chemistry
  • 2009 (First Publication: 15 July 2009)
  • In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to developExpand
  • Arzu Karakurt, Mehmet Abdullah Alagöz, Burcu Sayoğlu, Unsal Caliş, Sevim Dalkara
  • Medicine, Chemistry
  • European journal of medicinal chemistry
  • 2012 (First Publication: 1 November 2012)
  • Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activitiesExpand
  • Arzu Karakurt, Sevim Dalkara, Meral Ozalp, Süheyla Ozbey, Engin Kendi, James P. Stables
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2001 (First Publication: 1 May 2001)
  • In this study, oxime and oxime ether derivatives of anticonvulsant nafimidone [1-(2-naphthyl)-2-(imidozole-1-yl)ethanone] were prepared as potential anticonvulsant compounds. Nafimidone oxime wasExpand
  • Sevim Dalkara, Arzu Karakurt
  • Biology, Medicine
  • Current topics in medicinal chemistry
  • 2012 (First Publication: 1 May 2012)
  • Major advances in antiepileptic drug therapy have taken place since 1950s. In the first period, several antiepileptic drugs (AEDs) such as phenobarbital, diphenylhydantoin, ethosuximide,Expand
  • Jamal Kurdi, H Maurice, +4 authors Patrick du Souich
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1999 (First Publication: 1 September 1999)
  • 1 To investigate the effect of moderate hypoxia alone or combined with an inflammatory reaction or after 3-methylcholanthrene (3MC) pre-treatment on cytochrome P450 (P450), conscious rabbits wereExpand