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Voltage-activated ion channels open and close in response to changes in voltage, a property that is essential for generating nerve impulses. Studies on voltage-activated potassium (Kv) channels show that voltage-sensor activation is sensitive to the composition of lipids in the surrounding membrane. Here we explore the interaction of lipids with S1-S4(More)
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt età la diffusion(More)
Symmetry is one of the important cues for human and machine perception of the world. For over three decades, automatic symmetry detection from images/patterns has been a standing topic in computer vision. We present a timely, systematic, and quantitative performance evaluation of three state of the art discrete symmetry detection algorithms. This evaluation(More)
We present a novel and effective algorithm for affinely skewed rotation symmetry group detection from real-world images. We define a complete skewed rotation symmetry detection problem as discovering five independent properties of a skewed rotation symmetry group: 1) the center of rotation, 2) the affine deformation, 3) the type of the symmetry group, 4)(More)
Alzheimer's disease is the most common form of dementia, characterized by two pathological hallmarks: amyloid-β plaques and neurofibrillary tangles. The amyloid hypothesis of Alzheimer's disease posits that the excessive accumulation of amyloid-β peptide leads to neurofibrillary tangles composed of aggregated hyperphosphorylated tau. However, to date, no(More)
Gait is an attractive biometric for vision-based human identification. Previous work on existing public data sets has shown that shape cues yield improved recognition rates compared to pure motion cues. However, shape cues are fragile to gross appearance variations of an individual, for example, walking while carrying a ball or a backpack. We introduce a(More)
Symmetry is a pervasive phenomenon presenting itself in all forms and scales in natural and manmade environments. Its detection plays an essential role at all levels of human as well as machine perception. The recent resurging interest in computational symmetry for computer vision and computer graphics applications has motivated us to conduct a US NSF(More)
Chronic pain is a major therapeutic problem as the current treatment options are unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels (VGCCs), which are multi-complex proteins consisting of α1, β, γ, and α2δ subunits, play an important role in pain signaling. These channels are involved in neurogenic inflammation,(More)
BACKGROUND N-type Ca2+ channels (Ca(v)2.2) play an important role in the transmission of pain signals to the central nervous system. ω-Conotoxin (CTx)-MVIIA, also called ziconotide (Prialt®), effectively alleviates pain, without causing addiction, by blocking the pores of these channels. Unfortunately, CTx-MVIIA has a narrow therapeutic window and produces(More)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp recordings that hyperexcitability detected by clinical neurophysiological studies of ALS patients is recapitulated in induced pluripotent stem cell-derived motor neurons from ALS patients harboring(More)