Seungho Choi

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It was reported that the local recurrence would be caused by cancer stem cells acquiring chemo- and radio-resistance. Recently, one of the potential therapeutic targets for colorectal and other cancers has been identified, which is maternal embryonic leucine zipper kinase (MELK). MELK is known as an embryonic and neural stem cell marker, and associated with(More)
This paper relates to a method of enhancing speech quality by eliminating noise in speech presence intervals as well as in speech absence intervals based on speech absence probability. To determine the speech presence and absence intervals, we utilize the global soft decision. This decision makes the estimated statistical parameters of signal density models(More)
BACKGROUND Care coordination has received increased attention in recent years because it critically affects patient safety and care quality across services and settings. OBJECTIVE The effectiveness of systematically developed nurse navigator interventions for newly diagnosed cancer patients was evaluated. METHODS Seventy-eight patients participated in a(More)
Capillary zone electrophoresis was successfully applied to the enantiomeric purity determination of valsartan using acetyl-β-cyclodextrin (A-β-CD) as a chiral selector. Separations were carried out in a 50 µm, 64/56 cm fused-silica capillary. The optimized conditions included 25 mM phosphate buffer, pH 8.0, containing 10 mM A-β-CD as background electrolyte,(More)
Ginseng has been widely used for therapeutic and preventive purposes for thousands of years. However, orally administered ginseng has very low bioavailability and absorption in the intestine. Therefore, fermented ginseng was developed to enhance the beneficial effects of ginseng in the intestine. In this study, we investigated the molecular mechanisms(More)
Recent progress in chemotherapy has significantly increased its efficacy, yet the development of chemoresistance remains a major drawback. In this study, we show that GFRA1/GFRα1 (GDNF family receptor α 1), contributes to cisplatin-induced chemoresistance by regulating autophagy in osteosarcoma. We demonstrate that cisplatin treatment induced GFRA1(More)
In this paper, we propose a fast and practical head pose estimation scheme for eye-head controlled human computer interface with non-constrained background. The method we propose uses complete graph matching from thresholded images and the two blocks showing the greatest similarity are selected as eyes, we also locate mouth and nostrils in turn using the(More)
Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order to eliminate the limitations, herbal medicines have recently been developed for treatment of IBD. Peuraria Lobata (Peuraria L.) is one of the(More)
An experimental multimodal system combining natural input modes such as speech, lip movement, and gaze is proposed in this paper. It benefits from novel human-computer interaction (HCI) modalities and from multimodal integration for tackling the problem of the HCI bottleneck. This system allows the user to select menu items on the screen by employing speech(More)
Taken together, this study suggests that potato D-type cyclin genes are expressed differentially between in vitro and planta caused by intrinsic differences in physiology and gene action at the cellular and whole organism levels. Cyclin performs a pivotal role in control of the cell cycle by forming a complex with cyclin-dependent kinases (CDKs). In this(More)