Seung-Seok Lee

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A liquid chromatography-tandem mass spectrometric method for the simultaneous determination of sildenafil and its active N-demethylated metabolite, UK-103,320 in human plasma was developed. Sildenafil, UK-103,320 and the internal standard (DA-8159) were extracted from human plasma with dichloromethane at basic pH. A reverse-phase LC separation was performed(More)
KR-31543, (2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran, is a new neuroprotective agent for preventing ischemia-reperfusion damage. This study was performed to identify the metabolic pathway of KR-31543 in human liver microsomes and to characterize(More)
KR-31543, (2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran is a new neuroprotective agent for ischemia-reperfusion damage. The in vitro and in vivo metabolism of KR-31543 in rats has been studied by LC-electrospray mass spectrometry. Rat liver microsomal(More)
Abstract Direct attachment of piezoelectric transducers on hot targets raise formidable challenges as piezoelectric materials will lose their piezoelectric characteristic at elevated temperature due to Curie temperature limitation. In this paper, an attempt was made to build an integrated probe for hot target which enables to alleviate innovatively the(More)
This paper describes the application of ultrasound excited infrared thermography. In this technique, an ultrasound wave passing through a material with mechanical discontinuity such as a crack or disband causes temperature raise of that due to internal friction or thermo-mechanical effect and the localized heating area is visualized with infrared camera. In(More)
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