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Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength
The Ca2+ sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostaticExpand
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DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA
Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this potentiallyExpand
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A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.
Calcium (Ca(2+)) influx is required for the sustained secretion of insulin and is accompanied by a large rate of energy usage. We hypothesize that the energy usage reflects a processExpand
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High membrane permeability for melatonin
Cell-based and modeling studies support a mechanism of passive membrane diffusion for secretion of melatonin from the pineal gland.
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High Membrane Permeability for Melatonin
The pineal gland is the endocrine organ in the brain that synthesizes and secretes the circulating night hormone melatonin throughout the night. How is this hormone secreted? Is it byExpand
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Pattern of Ca2+ increase determines the type of secretory mechanism activated in dog pancreatic duct epithelial cells.
Intracellular calcium concentration ([Ca(2+)](i)) is a key factor controlling secretion from various cell types. We investigated how different patterns of [Ca(2+)](i) signals evoke salt secretion viaExpand
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Noradrenaline upregulates T-type calcium channels in rat pinealocytes.
KEY POINTS The mammalian pineal gland is a neuroendocrine organ that responds to circadian and seasonal rhythms. Its major function is to secrete melatonin as a hormonal night signal in response toExpand
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Control of granule mobility and exocytosis by Ca2+ -dependent formation of F-actin in pancreatic duct epithelial cells.
Elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)) triggers exocytosis of secretory granules in pancreatic duct epithelia. In this study, we find that the signal also controls granuleExpand
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Minimizing ATP depletion by oxygen scavengers for single-molecule fluorescence imaging in live cells
Significance Single-molecule live-cell imaging can answer many biological questions, but a significant obstacle is photobleaching of the dye molecules by dissolved oxygen. An excellent way to improveExpand
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Extracellular ATP protects pancreatic duct epithelial cells from alcohol-induced damage through P2Y1 receptor-cAMP signal pathway
Extracellular adenosine-5′-triphosphate (ATP) regulates cell death and survival of neighboring cells. The detailed effects are diverse depending on cell types and extracellular ATP concentration. WeExpand
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