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Inhibitory cross‐talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle
- Seung-Lark Hwang, Yong-Tae Jeong, H. Chang
- Biology, MedicineBritish journal of pharmacology
- 1 May 2013
The present study was undertaken to determine whether the chemical or genetic inhibition ER stress pathway targeting by ERK results in metabolic benefits in muscle cells.
New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.
Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase
The results demonstrate the beneficial effect of G. pentaphyllum on improving obesity and have elucidated the underlying molecular mechanisms.
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase.
Isodihydrocapsiate stimulates plasma glucose uptake by activation of AMP-activated protein kinase.
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Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK.
B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model
It is demonstrated that BTG2 regulates glucose homeostasis via upregulation of Nur77 in diabetic mice and participates in the regulation of hepatic glucoseHomeostasis, which means thatBTG2 might serve as a potential therapeutic target for combating metabolic dysfunction.
Low Molecular Weight Fucoidan Improves Endoplasmic Reticulum Stress-Reduced Insulin Sensitivity through AMP-Activated Protein Kinase Activation in L6 Myotubes and Restores Lipid Homeostasis in a…
The findings suggest that AMPK activation by LMWF could prevent metabolic diseases by controlling the ER stress-dependent pathway and that this beneficial effect of LMWf provides a potential therapeutic strategy for ameliorating ER stress -mediated metabolic dysfunctions.